Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome wide analysis of important transcription factors and histone modifications for prostate cancer progression

ABSTRACT: Genome wide analysis of important transcription factors and histone modifications for prostate cancer progression

PROVIDER: PRJNA612299 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11296617.fastq.gz	Fastqsanger.gz
	SRR11296618.fastq.gz	Fastqsanger.gz
	SRR11296619.fastq.gz	Fastqsanger.gz
	SRR11296620.fastq.gz	Fastqsanger.gz
	SRR11296621.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 33

Similar Datasets

Genome wide analysis of important transcription factors and histone modifications for prostate cancer progression

Project description:Prostate cancer is the most common cancer in men and androgen receptor (AR) downstream signalings promote prostate cancer progression. Although androgen deprivation therapy is effective for treating prostate cancer, most tumors relapsed as castration-resistant prostate cancer (CRPC). We performed ChIP-seq analysis to investigate the role of important transcription factors and histone modifications using AR positive prostate cancer cells, LNCaP, CRPC model cells, 22Rv1 and DU145 cells.

2021-05-01 | GSE146886 | GEO

Genome wide analysis of AR-associated factors and histone modifications in castration-resistant prostate cancer

Project description:Prostate cancer is the most common cancer in men and androgen receptor (AR) downstream signalings promote prostate cancer progression. Although androgen deprivation therapy is effective for treating prostate cancer, most of tumors relapsed as castration-resistant prostate cancer (CRPC). We performed ChIP-seq analysis to investigate the role of AR-associated factors and histone modifications using CRPC model cells, 22Rv1.

2019-04-01 | GSE123565 | GEO

Cancer associated fibroblasts play an important role in prostate cancer progression

Project description:Cancer associated fibroblasts play an important role in prostate cancer progression

| PRJNA882042 | ENA

Cancer associated fibroblasts play an important role in prostate cancer progression [RNA-Seq]

Project description:Cancer associated fibroblasts play an important role in prostate cancer progression [RNA-Seq]

| PRJNA882033 | ENA

Cancer associated fibroblasts play an important role in prostate cancer progression [ATAC-Seq]

Project description:Cancer associated fibroblasts play an important role in prostate cancer progression [ATAC-Seq]

| PRJNA882047 | ENA

Cancer associated fibroblasts play an important role in prostate cancer progression [ChIP-Seq]

Project description:Cancer associated fibroblasts play an important role in prostate cancer progression [ChIP-Seq]

| PRJNA882048 | ENA

Cancer associated fibroblasts play an important role in prostate cancer progression [RNA-Seq]

Project description:To understand the cell types changes in prostate cancer progression, we carried out scRNA-seq of prostates from different kinds of genetic mouse model. After that, we found fibroblasts were changed obviously during prostate cancer progression. To confirm the function of the fibroblasts, LNCap was used to cocultured with all kinds of fibroblasts in control or ADT condition. To find out the key enviroment factors induced firoblast changing, RNA-seq, ATAC-seq and ChIP-seq of fibroblast in different treatment were taken. And finally, ADT, TGF-β1, and sox4 were confirmed as contributors of the stroma cell changes, which provided new strategies for prostate cancer treatment. scRNA-seq were used to find out the cell lines diverisity of prostate cancer progressiom. RNA-seq of LNCap cocultured with different fibroblasts were taken to identify the pathway fibroblasts induced. RNA-seq, ATAC-seq and ChIP-seq of fibroblasts were carried out to find out the reason of fibroblast changes.

2023-06-22 | GSE213663 | GEO

Cancer associated fibroblasts play an important role in prostate cancer progression [ATAC-Seq]

2023-06-22 | GSE213665 | GEO

Cancer associated fibroblasts play an important role in prostate cancer progression [ChIP-Seq]

2023-06-22 | GSE213664 | GEO

An Integrated Proteomic Portrait of Prostate Cancer Progression

Project description:Cancer forms a local tumor that subsequently metastasizes to distant organs. In prostate cancer, the latter part of the trajectory is influenced by the inhibition of the androgen receptor (AR). The study of proteomic changes along disease progression may reveal insights into how prostate cancer evolves and open new therapeutic avenues. Here, we profile changes in protein abundance and post-translational modifications (PTMs) along the disease trajectory in patient-derived xenograft models. Our results suggest a key involvement of the RTK-RAS-MAPK pathway during disease progression. We highlight multiple alterations within this pathway including the tumor suppressors NF1 and ERF. Enhanced activity of cyclin-dependent kinases results in the engagement of various DNA repair pathways. Specific PTMs suggest changes in mitochondrial ATP synthesis, proteasomal activity, gene splicing, and TGF beta signaling. Finally, we show how different transcription factors engage with disease progression. A web resource is provided enabling the investigation of dynamic proteomic perturbations.

2024-10-30 | MSV000096252 | MassIVE

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data