Project description:An Infinium microarray platform (HorvathMammalMethylChip40) was used to generate DNA methylation data from n=168 blood samples of a transgenic sheep model of Huntington's disease. 84 transgenic sheep and age matched control sheep.
Project description:Human DNA methylation Beadchip v1.2 was used to profile n=475 samples from various brain regions of subjects with Huntington's disease and control samples. The main goal of the study was to relate Huntington's disease status to measures of epigenetic age acceleration based on DNA methylation data. To measure DNA methylation age, we used the epigenetic clock software described in Horvath S (n=2013) DNA methylation age of human tissues and cell types. Genome Biology.2013, 14:R115. DOI: 10.1186/10.1186/gb-2013-14-10-r115 PMID: 24138928.
Project description:An Infinium microarray platform (HorvathMammalMethylChip40) was used to generate DNA methylation data from mouse tissues of a heterozygous Huntingtin expansion knock-in (Q175) and wildtype (WT) controls. Mouse tissues: blood, liver, brain cortex, brain cerebellum, and striatum.
Project description:Primary neuron model of Huntington's Disease. 2 treatment groups: A) Infected 4 weeks prior with TRE-Htt-N853-18Q-expressing recombinant lentivirus, B) Infected 4 weeks prior with TRE-Htt-N853-82Q-expressing recombinant lentivirus Keywords: gene expression study
Project description:Human DNA methylation Beadchip v1.2 was used to profile buffy coat samples. The main goal of the study was to relate DNA methylation data to Huntington disease status (control, pre-manifest disease, manifest motor disease).