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Transcriptome and N6-methyladenosine RNA methylome analyses in aortic dissection and normal human aorta

ABSTRACT: Transcriptome and N6-methyladenosine RNA methylome analyses in aortic dissection and normal human aorta

PROVIDER: PRJNA612817 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11310800_1.fastq.gz	Fastqsanger.gz
	SRR11310800_2.fastq.gz	Fastqsanger.gz
	SRR11310801_1.fastq.gz	Fastqsanger.gz
	SRR11310801_2.fastq.gz	Fastqsanger.gz
	SRR11310802_1.fastq.gz	Fastqsanger.gz

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N6-methyladenosine RNA methylome analyses in aortic dissection and normal human aorta

Project description:N6-methyladenosine RNA methylome analyses in aortic dissection and normal human aorta

| PRJNA612821 | ENA

N6-methyladenosine RNA methylome analyses in aortic dissection and normal human aorta

Project description:To identify the m6A methylome in the aorta of patients with acute aortic dissection. MeRIP-seq and RNA-seq experiments of aortic media tissue samples obtained from AD patients and controls were conducted. Compared with control group, the upmethylated coding genes of AD were primarily enriched in the processes associated with extracellular fibril organization, while the genes with downmethylation were enriched in the processes associated with cell death regulation. Furthermore, many differentially methylated m6A sites (DMMSs) coding proteins were mainly annotated during the extracellular matrix and inflammatory responses.

2020-03-17 | GSE147027 | GEO

Epigenome analysis of ascending aorta from normal, aortic dissection and bicuspid aortic valve patients

Project description:Genome wide DNA methylation profiling of ascending aorta tissue samples from normal, aortic dissection and bicuspid aortic valve patients with aortic dilation. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across more than 450,000 CpGs in ascending aorta samples. Samples included 6 normal donors, 12 patients with aortic dissection and 6 patients with bicuspid aortic valve and dilated aorta.

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Epigenome analysis of aorta from normal and Stanford-A aortic dissection patients

Project description:Genome wide DNA methylation profiling of normal and ascending aorta tissue samples from normal and aortic dissection patients. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 485,512 CpGs in ascending aorta tissue samples. Samples included 4 normal donors and 4 patients with aortic dissection.

2022-11-02 | GSE202047 | GEO

Transcriptome analyses in aortic dissection and normal human aorta

2020-03-17 | GSE147026 | GEO

Transcriptome analyses in aortic dissection and normal human aorta

Project description:Transcriptome analyses in aortic dissection and normal human aorta

| PRJNA612822 | ENA

Genome-wide analysis of gene expression of ascending aorta from patients with acute Stanford type A aortic dissection

Project description:Differentially expressed genes were identified by comparing the gene expression profiling of dissected ascending aorta with that of control. Results provide important information to indicate pathogenesis of aortic dissection.

2014-12-31 | GSE52093 | GEO

Transcriptome and N6-Methyladenosine RNA Methylome Analyses in Aortic Dissection and Normal Human Aorta.

Project description:Objective: To investigate the N6-methyladenosine (m6A) modification and the expressions of the m6A regulatory genes in the acute aortic dissection (AD). Methods: MeRIP-seq and RNA-seq experiments of aortic media tissue samples obtained from AD (n = 4) and Controls (n = 4) were conducted. m6A methylation quantification was used to measure the total mRNA m6A level. The five m6A regulators mRNA expressions were analyzed by quantitative polymerase chain reaction (qPCR). Western blot analyses and immunofluorescence staining were used to detect the difference of METTL14 protein expression in the aortas of AD and Normal. Results: Among AD patients, we detected significantly elevated levels of m6A in total RNA. Compared with the normal group, the up methylated coding genes of AD were primarily enriched in the processes associated with extracellular fibril organization, while the genes with down methylation were enriched in the processes associated with cell death regulation. Furthermore, many differentially methylated m6A sites (DMMSs) coding proteins were mainly annotated during the extracellular matrix and inflammatory responses. Conclusions: These findings indicate that differential m6A methylation and m6A regulatory genes, including MTEEL14 and FTO, may act on functional genes through RNA modification, thereby regulating the pathogenesis of aortic dissection.

| S-EPMC8193080 | biostudies-literature

Epigenome analysis of aorta from normal and Stanford-A aortic dissection patients

Project description:Epigenome analysis of aorta from normal and Stanford-A aortic dissection patients

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Integrated Multi-Omics Profiling Reveals Neutrophil Extracellular Traps Promote Aortic Dissection

Project description:Adverse aortic remodeling increases the risk of aorta-related adverse events (AAEs) after thoracic endovascular aortic repair (TEVAR) and affects the overall prognosis of aortic dissection (AD). It is imperative to delve into the exploration of prognostic indicators to We performed single-cell transcriptomic and proteomic profiling of aortic lesions and peripheral blood samples, respectively, from patients with AD and healthy subjects. We then integrated single-cell RNA to identify phenotype-relevant subpopulations.

2024-11-01 | GSE254132 | GEO

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