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Meningeal gd T cells regulate anxiety like behaviors via Il17a signaling on Neurons (DG neurons)

ABSTRACT: Meningeal gd T cells regulate anxiety like behaviors via Il17a signaling on Neurons (DG neurons)

PROVIDER: PRJNA613633 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11356463_1.fastq.gz	Fastqsanger.gz
	SRR11356463_2.fastq.gz	Fastqsanger.gz
	SRR11356464_1.fastq.gz	Fastqsanger.gz
	SRR11356464_2.fastq.gz	Fastqsanger.gz
	SRR11356465_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

Meningeal gd T cells regulate anxiety like behaviors via Il17a signaling on Neurons (DG neurons)

Project description:Interleukin 17a (IL-17a) is a cytokine that has been highly conserved during evolution of the vertebrate immune system and widely studied in contexts of infection and autoimmunity. Recent studies in mouse models of maternal immune activation suggest that IL-17a is also linked to behavioral changes reminiscent of those seen under pathological conditions such as autism spectrum disorders (ASD)1 and in aggregation behavior in Caenorhabditis elegans2, raising the intriguing possibility that this cytokine might have evolved for the homeostatic regulation of neuronal activity. Here, by in-depth cellular and molecular characterization of a unique population of meningeal-resident gd17 T cells, we characterized the nearest central nervous system (CNS)-associated source of IL-17a under homeostasis. Meningeal gd T cell-derived IL-17a was associated with anxiety-like behaviors in mice, which partially depended on T-cell receptor engagement and commensal microbiota. IL-17a receptor was highly expressed in glutamatergic neurons under steady state and its genetic deletion decreased anxiety-like behavior in mice by shaping the transcriptional landscape and synaptic transmission of neurons in the medial prefrontal cortex (mPFC). From an evolutionary perspective, these findings suggest that IL-17a production by tissue-resident meningeal gd17 T cells may represent an evolutionary bridge between conserved anti-pathogen molecules and avoidance/survival behavioral traits in vertebrates.

2020-07-24 | GSE147260 | GEO

Meningeal gd T cells regulate anxiety like behaviors via Il17a signaling on Neurons

Project description:By characterizing the meningeal compartment of naive mice, here we explored a unique population of tissue-resident gd T cells, which we found to be the major source of IL-17A in the steady state meninges. gd T cells rapidly harbor meninges at perinatal stages and actively make IL-17A. Their IL-17A production was TCR-dependent but it occurred independent of commensal microbiota. The absence of meningeal gd T cells was related with risk-taking behavior in mice, which was dependent on the IL-17A signaling directly in the prefrontal cortex neurons. Our results demonstrate that tissue-resident meningeal gd T cell-derived IL-17A may represent an evolutionary bridge between anti-pathogen response and avoidance behavioral traits in vertebrates.

2020-07-24 | GSE132047 | GEO

Meningeal gd T cells regulate anxiety like behaviors via Il17a signaling on Neurons (PFC neurons)

Project description:Meningeal gd T cells regulate anxiety like behaviors via Il17a signaling on Neurons (PFC neurons)

| PRJNA613632 | ENA

Meningeal gd T cells regulate anxiety like behaviors via Il17a signaling on Neurons

Project description:Meningeal gd T cells regulate anxiety like behaviors via Il17a signaling on Neurons

| PRJNA545716 | ENA

Meningeal gd T cells regulate anxiety like behaviors via Il17a signaling on Neurons

Project description:Meningeal gd T cells regulate anxiety like behaviors via Il17a signaling on Neurons

| PRJNA613628 | ENA

Meningeal gd T cells regulate anxiety like behaviors via Il17a signaling on Neurons (PFC neurons)

2020-07-24 | GSE147261 | GEO

Meningeal gd T cells regulate anxiety like behaviors via Il17a signaling on Neurons

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-07-24 | GSE147262 | GEO

Meningeal cells contribute to postnatal cortical neurogenesis.

Project description:Postnatal brain neurogenesis in mammals is believed to be restricted to rare germinative remnants of the neuroepithelium. In this study, we discovered that, in the postnatal brain, a subset of embryonically derived progenitors is present in meningeal substructures. These cells migrate from the meningeal substructures to the retrosplenial and visual motor cortex and differentiate into (electrically) functional integrated neurons. Lineage tracing analysis revealed that this subset of neural progenitors originate largely from PDGFR+ cells. PDGFR-derived cells differentiate mostly into Satb2+ neurons in cortical layers I-IV. Thus, a reservoir of embryonically derived progenitors in the meninges contributes to postnatal cerebral cortical neurogenesis.

2016-11-23 | E-MTAB-4951 | biostudies-arrayexpress

DG vs superficial gonorrhoeae comparisons

Project description:transcription profiles of two groups each containing 5 strains of Disseminated gonorrhoeae (DG) and Undisseminated (superficial) gonorrhoeae (UG) were compared. An additional set of comparisons was done between 4 strains from group one Disseminated gonorrhoeae (DG) and another 4 strains from the same group.

2012-06-15 | E-MEXP-3254 | biostudies-arrayexpress

Meningeal natural killer cells and innate lymphoid cells 1 tune anxiety and memory via interferon-γ and acetylcholine

Project description:The mechanisms of communication between the brain and the neighboring meningeal immune cells are still unclear. Here we characterized the resident group 1 innate lymphoid cells in the meninges of adult mice, and identified ILC1/NK cell-derived interferon- and acetylcholine as mediators involved in the modulation of brain circuitries underlying anxiety-like behavior and memory. This discloses a new meningeal-to-brain communication mechanism that modulates brain functions under physiological conditions.

2023-05-05 | GSE212089 | GEO

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