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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

ABSTRACT: Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

PROVIDER: PRJNA614484 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11392110.fastq.gz	Fastqsanger.gz
	SRR11392111.fastq.gz	Fastqsanger.gz
	SRR11392112.fastq.gz	Fastqsanger.gz
	SRR11392113.fastq.gz	Fastqsanger.gz
	SRR11392114.fastq.gz	Fastqsanger.gz

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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Project description:Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

| PRJNA614483 | ENA

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Project description:Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Project description:Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Project description:T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained unclear, precluding a full understanding of the differentiation trajectories that underpin the heterogeneity of memory and effector T cells. Here, we used a series of high-dimensional approaches guided by single-cell RNA sequencing data to map the organizational structure of the human CD8+ memory T cell pool under physiological conditions. We identified two previously unrecognized subsets of clonally, epigenetically, functionally, phenotypically, and transcriptionally distinct stem-like CD8+ memory T cells. Progenitors lacking the inhibitory receptors programmed death-1 (PD-1) and T cell immunoreceptor with Ig and ITIM domains (TIGIT) were committed to a functional lineage, whereas progenitors expressing PD-1 and TIGIT were committed to a dysfunctional, exhausted-like lineage. Collectively, these data revealed the existence of parallel differentiation programs in the human CD8+ memory T cell pool, with potentially broad implications for the development of immunotherapies and vaccines.

2020-08-03 | GSE147397 | GEO

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

2020-08-03 | GSE147395 | GEO

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

2020-08-03 | GSE147394 | GEO

Two subsets of stem-like CD8<sup>+</sup> memory T cell progenitors with distinct fate commitments in humans.

Project description:T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained unclear, precluding a full understanding of the differentiation trajectories that underpin the heterogeneity of antigen-experienced T cells. We used a systematic approach guided by single-cell RNA-sequencing data to map the organizational structure of the human CD8+ memory T cell pool under physiological conditions. We identified two previously unrecognized subsets of clonally, epigenetically, functionally, phenotypically and transcriptionally distinct stem-like CD8+ memory T cells. Progenitors lacking the inhibitory receptors programmed death-1 (PD-1) and T cell immunoreceptor with Ig and ITIM domains (TIGIT) were committed to a functional lineage, whereas progenitors expressing PD-1 and TIGIT were committed to a dysfunctional, exhausted-like lineage. Collectively, these data reveal the existence of parallel differentiation programs in the human CD8+ memory T cell pool, with potentially broad implications for the development of immunotherapies and vaccines.

| S-EPMC7610790 | biostudies-literature

Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-08-03 | GSE147398 | GEO

CD62L expression level determines the cell fate of myeloid progenitors in mice and humans

Project description:CD62L expression level determines the cell fate of myeloid progenitors in mice and humans

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CD62L expression level determines the cell fate of myeloid progenitors in mice and humans

Project description:Through gene expression analysis of CMPs and GMPs at single cell levels, we identified CD62L as a marker to reveal the heterogeneity of CMPs and GMPs. We confirmed that the CD62L-low CMPs represent ‘bona fide’ CMPs, whereas CD62L-high CMPs are mostly restricted to GMP potentials both in mice and humans. In addition, we identified CD62L-neg GMPs as the most immature subsets in GMPs and Ly6c+CD62L-low and Ly6c+CD62L-high GMPs are skewed to neutrophil and monocyte differentiation, respectively. We performed gene expression profiling of CD62L-low CMPs, CD62L-high CMPs, CD62L-neg GMPs, CD62L-low GMPs, CD62L-high GMPs, bulk CMPs, and bulk GMPs.

2021-02-04 | GSE166065 | GEO

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