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BMP2 Signaling Activation Enhances Bone Metastases of Non-small-cell Lung Cancer

ABSTRACT: BMP2 Signaling Activation Enhances Bone Metastases of Non-small-cell Lung Cancer

PROVIDER: PRJNA623223 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11484272_1.fastq.gz	Fastqsanger.gz
	SRR11484272_2.fastq.gz	Fastqsanger.gz
	SRR11484273_1.fastq.gz	Fastqsanger.gz
	SRR11484273_2.fastq.gz	Fastqsanger.gz
	SRR11484274_1.fastq.gz	Fastqsanger.gz

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BMP2 Signaling Activation Enhances Bone Metastases of Non-small-cell Lung Cancer

Project description:Bone metastasis is one of the most frequent metastases of NSCLC and leads to poor prognosis. It has been reported that high expression of BMP2 in NSCLC indicates poor survival, but whether BMP2 contributes to NSCLC bone metastasis remains largely unknown.

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BMP2 signalling activation enhances bone metastases of non-small cell lung cancer.

Project description:Distant metastases occur when non-small cell lung cancer (NSCLC) is at late stages. Bone metastasis is one of the most frequent metastases of NSCLC and leads to poor prognosis. It has been reported that high expression of BMP2 in NSCLC correlates with poor survival, but whether BMP2 contributes to NSCLC bone metastasis remains largely unknown. The activation of BMP signalling is found in metastatic bone tumours of mice Lewis lung carcinoma and predicts poor survival in human NSCLC. BMP2 signalling activation can enhance bone metastasis of Lewis lung carcinoma. Moreover, BMP2 secreted by stroma fibroblasts can promote the migration and invasion of NSCLC cells. Besides, in combination with pre-osteoblast and LLCs, BMP2 could enhance the differentiation of macrophages into osteoclasts to play roles in the osteolytic mechanism of NSCLC bone metastasis. Interestingly, NSCLC cells can also enrich BMP2 to pre-osteoblasts to function in the osteoblastic mechanism. Our results firstly demonstrate the detailed mechanisms about what roles BMP2 signalling play in enhancing NSCLC bone metastases. These findings provide a new potential therapy choice for preventing bone metastases of NSCLC via the inhibition of BMP2 signalling.

| S-EPMC7521321 | biostudies-literature

Microarray on osteoblasts made from bone marrow stromal cells from Bmp2 flox/flox and Bmp2; Prx1-Cre mice

Project description:Enhanced BMP or canonical Wnt (cWnt) signaling are therapeutic strategies employed to enhance bone formation and fracture repair, but the mechanisms each pathway utilizes to specify cell fate of bone-forming osteoblasts remain poorly understood. Among all BMPs expressed in bone, we find that singular deficiency of Bmp2 blocks the ability of cWnt signaling to specify osteoblasts from limb bud or bone marrow progenitors. When exposed to cWnts, Bmp2-deficient cells fail to progress through the Runx2/Osx1 checkpoint and thus do not upregulate multiple genes controlling mineral metabolism in osteoblasts. Cells lacking Bmp2 after induction of Osx1 differentiate normally in response to cWnts, supporting pre-Osx1+ osteoprogenitors as a critical source and target of BMP2. Our analysis furthermore reveals Grainyhead-like 3 (Grhl3) is to date an unidentified transcription factor in the osteoblast gene regulatory network that is induced during bone development and bone repair, and acts upstream of Osx in a BMP2-dependent manner. The Runx2/Osx1 transition therefore receives critical regulatory inputs from BMP2 that are not compensated for by cWnt signaling, and this is mediated at least in part by induction and activation of Grhl3.

2016-10-19 | GSE79377 | GEO

Microarray analysis of human bone metastases samples

Project description:We performed microarray analysis with two different chip platforms, Affymetrix and Agilent, on bone metastasis samples from breast cancer patients with only bone metastases and metastases in bone and visceral organs. We collected bone metastases biopsies from breast cancer patients with only bone metastases and metastases in bone and visceral organs. RNA was extracted from these samples and subjected to microarray analysis with the Agilent platform. Data were compared with a signsture obtained with the Affymetrix platform, to obtain a signature of differentially regulated genes between the two groups of patients This Series represents the Agilent data only. The Affymetrix data are provided in GEO Series GSE11078.

2011-12-29 | E-GEOD-34485 | biostudies-arrayexpress

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Project description:Rattus norvegicus Bmp2, bone morphogenetic protein 2 [Source:RGD Symbol;Acc:2211], is differentially expressed in 34 experiment(s);

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Bmp2

Project description:Rattus norvegicus Bmp2, bone morphogenetic protein 2 [Source:RGD Symbol;Acc:2211], is expressed in 2 baseline experiment(s);

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BMP2

Project description:Monodelphis domestica BMP2, bone morphogenetic protein 2 [Source:NCBI gene;Acc:100031674], is expressed in 1 baseline experiment(s);

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Project description:Sus scrofa BMP2, bone morphotic protein 2 [Source:VGNC Symbol;Acc:VGNC:95488], is expressed in 2 baseline experiment(s);

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Project description:Macaca mulatta BMP2, bone morphogenetic protein 2 [Source:HGNC Symbol;Acc:HGNC:1069], is differentially expressed in 1 experiment(s);

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