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Virtual memory T-cells orchestrate extra-lymphoid responses conducive to resident memory

ABSTRACT: Virtual memory T-cells orchestrate extra-lymphoid responses conducive to resident memory

PROVIDER: PRJNA624067 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11518309.fastq.gz	Fastqsanger.gz
	SRR11518310.fastq.gz	Fastqsanger.gz
	SRR11518311.fastq.gz	Fastqsanger.gz
	SRR11518312.fastq.gz	Fastqsanger.gz
	SRR11518313.fastq.gz	Fastqsanger.gz

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Virtual memory T-cells orchestrate extra-lymphoid responses conducive to resident memory

Project description:A primary immune response is typically initiated in secondary lymphoid organs. Virtual memory CD8+ T (TVM) cells are antigen-inexperienced T cells of a central-memory phenotype, acquired through self antigen-driven homeostatic proliferation. Unexpectedly, here we find that, TVM cells are composed of CCR2+ and CCR2- subsets that differentially elaborate a spectrum of effector- and memory-poised functions directly in the tissue. During a primary flu infection, TVM cells rapidly infiltrate the lung in the first day and execute early viral control. TVM cells that recognize viral antigen are retained in the tissue, clonally expand independent of secondary lymphoid organs, and preferentially give rise to tissue-resident memory cells. By orchestrating an extra-lymphoid primary response, heterogenous TVM cells bridge innate reaction and adaptive memory directly in the infected tissue.

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The Heterogenicity of Virtual Memory CD8 T Cells in Relation to Their Cytokine Dependent Development

Project description:The development of virtual memory CD8 T cells is dependent on IL-4, type I interferon, and IL-15. However, it remains unclear whether these cytokines individually contribute to the generation of specific subsets of virtual memory CD8 T cells. In this study, virtual memory CD8 T cells were categorized into four subsets based on Ly6C and Sca-1 expression, and their development was examined using knock-out mice lacking IFNAR1, IL-4, or IL-15Rα. Notably, both Ly6C+ Sca-1+ and Ly6C- Sca-1+ subsets were significantly reduced in the spleen of IFNAR1 knock-out mice, while the proportion of Ly6C+ Sca-1- VM CD8 T cells was reduced in IL-4-deficient mice. In IL-15Rα knock-out mice, both the Ly6C+ Sca-1- and Ly6C- Sca-1- subsets were significantly reduced. Bulk RNA sequencing analysis revealed distinct gene expression patterns in naïve cells, true memory cells, and four virtual memory cells subsets. Specifically, Ly6C+ subsets were enriched with IL-15 signal-related genes, whereas Ly6C- subsets and true memory cells were enriched for cell cycle-related genes. Functionally, the Ly6C+ subsets exhibited higher production of IFN-γ, TNF-α, and perforin compared to the Ly6C- subsets. Overall, this study demonstrates the heterogeneity of virtual memory CD8 T cells and highlights the cytokine-dependent nature for their development.

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Generation of virtual memory from relatively highly self-reactive is a mechanism of self-tolerance

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Analysis of gene-expression in normal, unmanipulated naïve (CD44lo/CD49dlo; CD5lo/CD5hi) and Virtual memory (CD44hi/CD49dlo) T cells

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Effect of Aiolos on virtual memory T cell differentiation and function [RNA-Seq]

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Effect of Aiolos on virtual memory T cell differentiation and function [ATAC-Seq]

Project description:Effect of Aiolos on virtual memory T cell differentiation and function [ATAC-Seq]

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