Project description:The Tasmanian devil, a marsupial carnivore, is endangered due to the emergence of a clonally transmissible cancer known as Devil Facial Tumor Disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, mitochondrial genome analysis, as well as deep sequencing of the DFTD transcriptome and miRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor, and suggest that the disease is of Schwann cell origin. On the basis of these results we have generated a diagnostic marker for DFTD, and identify a suite of genes of relevance to DFTD pathology and transmission. We provide a genomic dataset for the Tasmanian devil, which is applicable to cancer diagnosis, disease evolution and conservation biology. This submission contains only small RNA sequence data from this study. Small RNA (18 - 24 nt) sequences from 15 Tasmanian devil (Sarcophilus harrisii) tissue samples

2010-01-01 | E-GEOD-18352 | biostudies-arrayexpress

The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer (small RNA sequencing)

2010-01-01 | GSE18352 | GEO

Apostichopus japonicus breed:domesticated

Project description:Apostichopus japonicus breed:domesticated Transcriptome or Gene expression

| PRJNA262477 | ENA

Argyrosomus japonicus breed:Dusky Kob

Project description:Argyrosomus japonicus breed:Dusky Kob Raw sequence reads

| PRJNA1033436 | ENA

Inimicus japonicus isolate:Geomun-do (34.1 N, 127.18 E), Yeosu, Republic of Korea

Project description:Inimicus japonicus isolate:Geomun-do (34.1 N, 127.18 E), Yeosu, Republic of Korea Raw sequence reads

| PRJNA633000 | ENA