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Gene expression profiles of basophil progenitors from mouse bone marrow

ABSTRACT: Gene expression profiles of basophil progenitors from mouse bone marrow

PROVIDER: PRJNA625970 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11563229_1.fastq.gz	Fastqsanger.gz
	SRR11563229_2.fastq.gz	Fastqsanger.gz
	SRR11563230_1.fastq.gz	Fastqsanger.gz
	SRR11563230_2.fastq.gz	Fastqsanger.gz
	SRR11563231_1.fastq.gz	Fastqsanger.gz

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Gene expression profiles of basophil progenitors from mouse bone marrow

Project description:To find genes governing basophil development or functional maturation, we analyzed the gene expression profiles of basophil progenitors by RNA-sequencing.

2023-10-31 | GSE148857 | GEO

Gene expression profiles of Nfil3-deficient basophil progenitors from mouse bone marrow

Project description:Gene expression profiles of Nfil3-deficient basophil progenitors from mouse bone marrow

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Gene expression profiles of basophil progenitors, CD34- pre-basophils and mature basophils

Project description:In this study, we explored gene expression profiles of CD34-CLEC12Ahi pre-basophils isolated from the bone marrow as well as CD34-CLEC12Alo mature basophils from the bone marrow and CD34+ basophil progenitors. We revealed that the gene expression of mature basophils isolated from the bone marrow and spleen resembled each other whereas pre-basophils and mature basophils showed distinct gene expression profiles.

2023-03-21 | GSE206591 | GEO

Gene expression profiles of Nfil3-deficient basophil progenitors from mouse bone marrow

Project description:To find genes regulated by Nfil3 during development or functional maturation, we analyzed the gene expression profiles of basophil progenitors by RNA-sequencing.

2023-10-31 | GSE214147 | GEO

Single cell RNA sequencing of murine basophil/mast cell progenitors and granulocyte/monocyte progenitors

Project description:We have performed single cell RNA sequencing of murine bone marrow progenitors to study the early differentiation into the mast cell and basophil lineages.

2018-03-29 | GSE106973 | GEO

Microarray analysis of mouse bone marrow hematopoietic progenitors after bone marrow transplant

Project description:Microarray analysis of mouse bone marrow hematopoietic progenitors after bone marrow transplant

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RNA-seq analysis of mouse bone marrow hematopoietic progenitors after bone marrow transplant

Project description:RNA-seq analysis of mouse bone marrow hematopoietic progenitors after bone marrow transplant

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Gene expression profiles of basophil progenitors, CD34- pre-basophils and mature basophils

Project description:Gene expression profiles of basophil progenitors, CD34- pre-basophils and mature basophils

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Microarray analysis of mouse bone marrow hematopoietic progenitors

Project description:Microarray analysis of mouse bone marrow hematopoietic progenitors

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E-cadherin marks the early commitment of murine hematopoietic progenitors to the basophil and mast cell fate

Project description:E-cadherin is a calcium-dependent cell-cell adhesion molecule extensively studied for its involvement in tissue formation, epithelial cell behavior and suppression of cancer; however its expression in the hematopoietic system hasn't received much attention. Combining single-cell RNA sequencing analyses and immunophenotyping, we revealed expression of E-cadherin in the basophil and mast cell lineages. No defect in basophil and mast cell differentiation was observed in mice lacking E-cadherin in the hematopoietic system, supporting that E-cadherin is not required per se for basophil and mast cell differentiation. Yet, we evidenced that granulocyte-monocyte progenitors expressing high levels of E-cadherin have an enriched capacity to differentiate into basophils and mast cells. Importantly, E-cadherin expression is observed on committed progenitors prior to the expression of other reported markers of these lineages. We named those progenitors pro-BMPs (pro- basophil and mast cells progenitors). Using RNA-sequencing, we demonstrated the transcriptional priming of pro-BMPs to the basophil and mast cell lineages.

2021-01-01 | GSE132122 | GEO

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