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Arginine acts as an epigenetic modulator to regulate mitochondrial function

ABSTRACT: Arginine acts as an epigenetic modulator to regulate mitochondrial function

PROVIDER: PRJNA626456 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11569328.fastq.gz	Fastqsanger.gz
	SRR11569329.fastq.gz	Fastqsanger.gz
	SRR11569330.fastq.gz	Fastqsanger.gz
	SRR11569331.fastq.gz	Fastqsanger.gz
	SRR11569332.fastq.gz	Fastqsanger.gz

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Arginine acts as an epigenetic modulator to regulate mitochondrial function

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FOXM1 acts sexually dimorphically to regulate functional B-cell mass (ChIP-Seq)

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Mina53 demethylates histone 4 arginine 3 asymmetric di-methylation to regulate neural stem/progenitor cell identity

Project description:Arginine methylation of histones plays a critical role in regulating gene expression. The writers (methyltransferases) and readers of methylarginine marks are well-known, but the erasers－arginine demethylases－remain mysterious. Here we identify Myc-induced nuclear antigen 53 (Mina53), a jumonji C domain containing protein, as an arginine demethylase for removing asymmetric di-methylation at arginine 3 of histone H4 (H4R3me2a). Using photoaffinity capture method, we first identified Mina53 as an interactor of H4R3me2a. Biochemical assays in vitro and in cells characterized the arginine demethylation activity of Mina53. Molecular dynamics simulations provide further atomic-level evidence that Mina53 acts on H4R3me2a. In a transgenic mouse model, specific Mina53 deletion in neural stem/progenitor cells prevented H4R3me2a demethylation at distinct genes clusters, dysregulating genes important for neural stem/progenitor cell proliferation and differentiation, and consequently impairing the cognitive function of mice. Collectively, we identify Mina53 as a bona fide H4R3me2a eraser, expanding the understanding of epigenetic gene regulation.

2024-10-22 | PXD045247 | Pride

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