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ABSTRACT: Comparison of Peri-arteriolar and peri-sinusoidal stromal cells in adult bone marrow

PROVIDER: PRJNA626582 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11573985.fastq.gz	Fastqsanger.gz
	SRR11573986.fastq.gz	Fastqsanger.gz
	SRR11573987.fastq.gz	Fastqsanger.gz
	SRR11573988.fastq.gz	Fastqsanger.gz
	SRR11573989.fastq.gz	Fastqsanger.gz

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Project description:In the bone marrow, CXCL12 and IL7 are essential for B cell differentiation whereas hematopoietic stem cells (HSC) maintenance requires SCF and CXCL12. Previous studies, including ours, indicate that peri-sinusoidal stromal (PSS) cells are heterogeneous and that part of them express and are the main source of IL7. Our single cell qPCR and transcriptomic analysis demonstrate that SCF, CXCL12 and IL7 are co-expressed by a unique peri-sinusoidal stromal cell subset.

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