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Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL

ABSTRACT: Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL

PROVIDER: PRJNA627880 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11604776_1.fastq.gz	Fastqsanger.gz
	SRR11604776_2.fastq.gz	Fastqsanger.gz
	SRR11604777_1.fastq.gz	Fastqsanger.gz
	SRR11604777_2.fastq.gz	Fastqsanger.gz
	SRR11604778_1.fastq.gz	Fastqsanger.gz

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Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL

Project description:Mutations in genes encoding the various subunits of the SWI/SNF chromatin remodeling complex are frequently observed in different human cancers. In diffuse large B-cell lymphoma (DLBCL), genetic changes in BCL7A, a subunit of the SWI/SNF complex, have been recently reported but the functional role of such genetic changes remains unknown. BCL7A mutations concentrate at the first exon and the most frequently mutated hotspot is the splice donor site of the first intron. By using in vitro and in vivo analyses, we show that restoration of BCL7A drives a tumor suppressor-like phenotype. Further, we found that splice site mutations block the tumor suppressor phenotype and prevent BCL7A from binding to the SWI/SNF complex. Finally, we identified that the SWI/SNF complex accumulates mutations in a third of DLBCL tumors, especially in the GCB subtype. These discoveries highlight the tumor suppressor role of BCL7A mutations in DLBCL, and suggest that the SWI/SNF complex is involved in DLBCL pathogenesis.

2020-11-20 | GSE149277 | GEO

Frequent mutations on amino-terminal BCL7A domain compromise its tumor suppressor role in DLBCL.

2020-10-21 | PXD014795 | Pride

RNA-seq Analysis of 14-day-old WT, bcl7a(brip3), bcl7b(brip4), bcl7a bcl7b(brip3 brip4), bcl7a bcl7b brm-3(brip3 brip4 brm-3) and bcl7a bcl7b brm-1(brip3 brip4 brm-1) seedlings under short day condition

Project description:Purpose：Examination of global gene expression of 14-day-old WT, bcl7a(brip3), bcl7b(brip4), bcl7a bcl7b(brip3 brip4), bcl7a bcl7b brm-3(brip3 brip4 brm-3) and bcl7a bcl7b brm-1(brip3 brip4 brm-1) seedlings under short day condition. Methods: Total RNA was extracted from 14-day-old Arabidopsis seedlings under short-day conditions using TRIzol reagent (Invitrogen) following the manufacturer's instructions. RNAs from three biological replicates was sequenced. separately at Novogene, using Illumina Hiseq X-Ten (Sequencing method: Hiseq-PE150). The paired-end RNA-seq reads were quantified by Salmon(Patro et al., 2017) (v1.5.1) with parameters -k 31 and --type quasi. Salmon index was generated using AtRTD2.fa as the reference transcriptome. The gene quantification files of all samples were used as inputs (TPM values) for differential gene expression analysis by DESeq2(Love et al., 2014) v3.10. To analyze differential gene expression in all samples, we used “parametric” Fit type, “ratio” method for estimate Size Factors and Wald significance test function provided by DESeq2. Conclusions: Our study represents the first detailed analysis of bcl7a(brip3), bcl7b(brip4), bcl7a bcl7b(brip3 brip4), bcl7a bcl7b brm-3(brip3 brip4 brm-3) and bcl7a bcl7b brm-1(brip3 brip4 brm-1) transcriptomes, with biologic replicates, generated by RNA-seq technology.

2024-01-03 | GSE215151 | GEO

DLBCL

Project description:DLBCL

| PRJNA1118307 | ENA

BCL7A is silenced by hypermethylation to promote acute myeloid leukemia

Project description:Differential expression analysis was performed to determine pathways and genes altered after BCL7A expression restoration.

2023-04-07 | GSE226604 | GEO

bcl7a

Project description:Xenopus tropicalis bcl7a, BCL7A, BAF complex component [Source:Xenbase;Acc:XB-GENE-5754603], is expressed in 1 baseline experiment(s);

| ENSXETG00000003772 | ExpressionAtlas

bcl7a

Project description:Xenopus tropicalis bcl7a, BCL7A, BAF complex component [Source:Xenbase;Acc:XB-GENE-5754603], is differentially expressed in 1 experiment(s);

| ENSXETG00000003772 | ExpressionAtlas

bcl7a

Project description:Danio rerio bcl7a, BAF chromatin remodeling complex subunit BCL7A [Source:NCBI gene;Acc:57952], is differentially expressed in 1 experiment(s);

| ENSDARG00000052907 | ExpressionAtlas

bcl7a

Project description:Danio rerio bcl7a, BAF chromatin remodeling complex subunit BCL7A [Source:NCBI gene;Acc:57952], is expressed in 1 baseline experiment(s);

| ENSDARG00000052907 | ExpressionAtlas

Bcl7a

Project description:Rattus norvegicus Bcl7a, BAF chromatin remodeling complex subunit BCL7A [Source:RGD Symbol;Acc:1585128], is differentially expressed in 22 experiment(s);

| ENSRNOG00000056017 | ExpressionAtlas

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