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Genome wide profiling of chromatin accessibilities in murine mononuclear phagocyte lineage progenitor cells

ABSTRACT: Genome wide profiling of chromatin accessibilities in murine mononuclear phagocyte lineage progenitor cells

PROVIDER: PRJNA629970 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11681104.fastq.gz	Fastqsanger.gz
	SRR11681105.fastq.gz	Fastqsanger.gz
	SRR11681106.fastq.gz	Fastqsanger.gz
	SRR11681107.fastq.gz	Fastqsanger.gz
	SRR11681108.fastq.gz	Fastqsanger.gz

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Genome wide profiling of chromatin accessibilities in murine mononuclear phagocyte lineage progenitor cells

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Project description:To understand the mechanism underlying monocyte and dendritic cell development through the regulation of Irf8 expression by the 56 kb downstream (+56 kb) Irf8 enhancer, we performed transcriptome analysis of bone marrow cells and splenocytes from wild-type, the Irf8 +56 kb enhancer-deficient, and IRF8-deficient mice. Taken together with the epigenetic profiling of mononuclear phagocyte lineage cells in these mice, the Irf8 +56 kb enhancer-mediated high Irf8 expression in hematopoietic progenitor cells promote type 1 classical dendritic cell (cDC1) differentiation, while low Irf8 expression in progenitors led to Ly6C+ monocyte development.

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