Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression profile of IL4I1 knockout CAS-1 glioblastoma cells

ABSTRACT: Gene expression profile of IL4I1 knockout CAS-1 glioblastoma cells

PROVIDER: PRJNA630471 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Gene expression profile of IL4I1 knockout CAS-1 glioblastoma cells

Project description:Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor malignancy and suppresses anti-tumor immunity. Hitherto, indoleamine-2,3-dioxygenase 1 (IDO1) or tryptophan- 2, 3-dioxygenase (TDO2) are recognized as the main Trp-catabolizing enzymes (TCEs) responsible for the generation of AHR agonists. Here, the ability of the aromatic L-amino acid oxidase, interleukin 4 induced 1 (IL4I1), to activate the AHR was investigated using IL4I1 knockout CAS-1 glioblastoma cells.

2020-08-19 | GSE149910 | GEO

RNA-sequencing analysis of wild-type, Lao1 knockout and Lao1/Il4i1 double knockout mice under normal and DSS-treated conditions

Project description:RNA-sequencing was performed on intestinal tissues from wild-type, Lao1 knockout, and Lao1/Il4i1 double knockout germ-free mice under normal and 24-hour DSS treatment conditions to identify regulators of intestinal stress response. Lao1 controls 80.1% of DSS-induced transcriptional differences, with Il4i1 adding 14.7%. Lao1 mainly regulates oxidative phosphorylation and cell migration pathways, while Il4i1 modulates lipid metabolism and ER stress responses. These findings establish Lao1 and Il4i1 as hierarchical regulators of intestinal stress responses.

2025-12-09 | GSE312324 | GEO

AHR activation in glioblastoma cells [I3P_HPP_PP_U87_U87]

Project description:The objective of this study was to analyze AHR activation through aromatic amino acid metabolism. To this end, glioblastoma cells were exposed to aromatic amino acid derived metabolites and their ability to activate AHR was analysed. In addition, AHR activation was evaluated in glioblastoma cells expressing IL4I1, an aromatic amino acid degrading enzyme, with or without shRNA mediated knockdown of AHR.

2020-08-19 | GSE129976 | GEO

AHR activation in glioblastoma cells [I3CA_U87]

2020-08-19 | GSE129974 | GEO

AHR activation in glioblastoma cells [FICZ_KynA]

2020-08-19 | GSE129972 | GEO

AHR activation in glioblastoma cells [IL4I1_shAHR_U87]

2020-08-19 | GSE129977 | GEO

RNA-sequencing analysis of wild-type, Lao1 knockout and Lao1/Il4i1 double knockout mice under normal and DSS-treated conditions

Project description:RNA-sequencing analysis of wild-type, Lao1 knockout and Lao1/Il4i1 double knockout mice under normal and DSS-treated conditions

| PRJNA1373031 | ENA

Effect of POLDIP2 knockout in ARPE-19 cells

Project description:To study the function of AMD-associated gene POLDIP2 in retinal pigment epithelial (RPE) cells, we used CRISPR/Cas to knockout POLDIP2 in the human RPE cell line ARPE19. We then performed RNA-seq to profile the transcriptome of wildtype ARPE19 and POLDIP2 knockout.

2022-10-01 | GSE207158 | GEO

Gene expression profiling of IL4I1 KO and WT CD8+ T-cell subsets from TCL1-AT mice

Project description:Analysis of the effect of IL4I1 on gene expression of CD8 T-cells in CLL

2020-08-19 | GSE149846 | GEO

Gene expression profile of murine proneural glioblastoma

Project description:Gene expression profile of murine proneural glioblastoma

| PRJNA716179 | ENA