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Homo sapiens

ABSTRACT: Genome-wide gene expression profiling post GNL3 knockdown in human neural progenitor cells

PROVIDER: PRJNA631411 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11746641_1.fastq.gz	Fastqsanger.gz
	SRR11746641_2.fastq.gz	Fastqsanger.gz
	SRR11746642_1.fastq.gz	Fastqsanger.gz
	SRR11746642_2.fastq.gz	Fastqsanger.gz
	SRR11746643_1.fastq.gz	Fastqsanger.gz

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Project description:RNA sequencing of human neural progenitor cells, SK-N-SH, following CHD8 knockdown

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RNA-seq of of human (Homo sapiens), gorilla (Gorilla gorilla) and cynomolgus macaque (Macaca fascicularis) iPSC and iPSC-derived NPC cell lines

Project description:RNA-seq samples from 3 species across a differentiation from induced pluripotent stem cells to neural progenitor cells were generated to study gene expression evolution. Briefly, previously generated urinary stem cell derived iPSCs of 3 human (Homo sapiens) individuals (3 clones), 1 gorilla (Gorilla gorilla) individual and fibroblast derived cynomolgus macaque (Macaca fascicularis) iPSCs of 2 individuals (4 clones) (Geuder et al. 2021) were differentiated to neural progenitor cells via dual-SMAD inhibition as three-dimensional aggregation culture (Chambers et al. 2009; Ohnuki et al. 2014). Bulk RNA-seq libraries of iPSCs and NPCs were generated using prime-seq protocol (Janjic et al. 2022).

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