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4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes

ABSTRACT: 4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes

PROVIDER: PRJNA631421 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11744387.fastq.gz	Fastqsanger.gz
	SRR11744388.fastq.gz	Fastqsanger.gz
	SRR11744389.fastq.gz	Fastqsanger.gz
	SRR11744390.fastq.gz	Fastqsanger.gz

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4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes

Project description:Pathogens must counteract a wide array of antimicrobial responses, including the reactive oxygen species (ROS) burst. ROS mediated oxidation of host membrane poly-unsaturated fatty acids (PUFAs) leads to the production of the toxic alpha-beta carbonyl 4-hydroxy-2-nonenal (4-HNE). 4-HNE has been studied extensively in the context of sterile inflammation but understanding of its role during bacterial infection remains limited. In this work we found that 4-HNE is generated during bacterial infection and that the intracellular pathogen Listeria monocytogenes induces a specific set of genes in response to 4-HNE exposure.

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