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MiR-146a regulates many lncRNAs in RAS induced senescence [miR-CLIP

ABSTRACT: miR-146a regulates many lncRNAs in RAS induced senescence [miR-CLIP

PROVIDER: PRJNA631764 | ENA |

REPOSITORIES: ENA

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Dataset's files

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			Action	DRS
	SRR11772800.fastq.gz	Fastqsanger.gz
	SRR11772801.fastq.gz	Fastqsanger.gz
	SRR11772802.fastq.gz	Fastqsanger.gz
	SRR11772803.fastq.gz	Fastqsanger.gz
	SRR11772816.fastq.gz	Fastqsanger.gz

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miR-146a regulates many lncRNAs in RAS induced senescence [miR-CLIP]

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miR-146a regulates many lncRNAs in RAS induced senescence [miR-CLIP]

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miR-146a regulates many lncRNAs in RAS induced senescence [miR-CLIP

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Mir-146a wild-type 3ʹ sequence identity is dispensable for proper innate immune function in vivo

Project description:A long-prevailing model has held that the “seed” region (nucleotides 2-8) of a microRNA is typically sufficient to mediate target recognition and repression. However, numerous recent studies, both within the context of defining miRNA/target pairs by direct physical association and by directly assessing this model in vivo in C. elegans have brought this model into question. To test the importance of miRNA 3' pairing in vivo, in a mammalian system, we engineered a mutant murine mir-146a allele in which the 5' half of the mature microRNA retains the sequence of the wild-type mir-146a but the 3ʹ half has been altered to be anti-complementary to the wild-type miR-146a sequence. Mice homozygous or hemizygous for this mutant allele are phenotypically indistinguishable from wild-type controls and do not recapitulate any of the immunopathology previously described for mir-146a-null mice. Our results strongly support the conclusion that 3ʹ pairing is dispensable in the context of the function of a key mammalian microRNA.

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mml-mir-146a

Project description:Macaca mulatta mml-mir-146a, mml-mir-146a [Source:miRBase;Acc:MI0007634], is differentially expressed in 1 experiment(s);

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ocu-mir-146a

Project description:Oryctolagus cuniculus ocu-mir-146a, ocu-mir-146a [Source:miRBase;Acc:MI0039304], is expressed in 1 baseline experiment(s);

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ssc-mir-146a

Project description:Sus scrofa ssc-mir-146a, ssc-mir-146a [Source:miRBase;Acc:MI0015926], is expressed in 1 baseline experiment(s);

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Project description:Macaca mulatta mml-mir-146a, mml-mir-146a [Source:miRBase;Acc:MI0007634], is expressed in 2 baseline experiment(s);