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Transcriptional landscape of three exhausted CD8 T cell subsets

ABSTRACT: Transcriptional landscape of three exhausted CD8 T cell subsets

PROVIDER: PRJNA631925 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11776879.fastq.gz	Fastqsanger.gz
	SRR11776880.fastq.gz	Fastqsanger.gz
	SRR11776881.fastq.gz	Fastqsanger.gz

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Project description:CD8 T cells normally differentiate from resting naÃ¯ve T cells into function effector and then memory CD8 T cells following acute infections. During chronic viral infections, however, virus-specific CD8 T cells often become exhausted. We used microarrays to examine the gene expression differences between naive, effector, memory and exhausted virus-specific CD8 T cells following lymphocytic choriomeningitis virus infection. Experiment Overall Design: Three or four independent samples were sorted by flow cytometry for each cell type (naive, effector, memory and exhausted) virus-specific CD8 T cells. RNA was extracted and hybridized to Affymetrix microarrays.

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