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Microglial remodeling of the extracellular matrix promotes synapse plasticity [Neuronal nuclei]

ABSTRACT: Microglial remodeling of the extracellular matrix promotes synapse plasticity [Neuronal nuclei]

PROVIDER: PRJNA633364 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11804000.fastq.gz	Fastqsanger.gz
	SRR11803997.fastq.gz	Fastqsanger.gz
	SRR11803998.fastq.gz	Fastqsanger.gz
	SRR11803999.fastq.gz	Fastqsanger.gz

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Microglial remodeling of the extracellular matrix promotes synapse plasticity

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Project description:Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we define a molecular interaction between neurons and microglia that drives experience-dependent synapse remodeling in the hippocampus. We find that the cytokine interleukin-33 (IL-33) is expressed by adult hippocampal neurons in an experience-dependent manner and defines a neuronal subset primed for synaptic plasticity. Loss of neuronal IL-33 or the microglial IL-33 receptor leads to impaired spine plasticity, reduced newborn neuron integration, and diminished precision of remote fear memories. Memory precision and neuronal IL-33 are decreased in aged mice, and IL-33 gain of function mitigates age-related decreases in spine plasticity. We find that neuronal IL-33 instructs microglial engulfment of the extracellular matrix (ECM) and that its loss leads to impaired ECM engulfment and a concomitant accumulation of ECM proteins in contact with synapses. These data define a cellular mechanism through which microglia regulate experience-dependent synapse remodeling and promote memory consolidation.

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