Project description:We carried out the analyses of chromosome variations between low-grade and high-grade gliomas in Chinese population. We found out the differences in chromosomes, cytobands, genes, pathways and GO functions. To identify the glioma tissue-specific genomic alterations and compare the genomic variations between low-grade and high-grade gliomas.
Project description:Diffuse low and high grade glioma are primary brain tumors arising from gllial cells. They are subdivided into three groups: IDH1-mutant oligodendrogliomas, IDH1-mutant astrocytomas and IDH1-Wild Type glioblastomas. Cellular tools to study these tumors remains poors, specially for low grades gliomas. We constituted a biobank of 12 patient-derived cell lines, from IDH1-mutant and wild type gliomas, then charactrized them to test their relevance as in vitro models.
Project description:This dataset comprises high-resolution LC–MS/MS proteomic profiles of human normal brain tissue, low-grade glioma, and high-grade glioma samples, enabling comparative analysis of grade-associated protein expression changes and supporting biomarker discovery and mechanistic studies.