Project description:An inhibitory effect of novobiocin on bop transcription was reported for the NRC1 strain of Hbt. salinarum ([17] Yang and DasSarma, 1990, [18] Yang et al, 1996), but its influence in strain R1 has not beeen known yet. We were interested to see the genome wide influences of novobiocin on transcription in Hbt. salinarum. Therefore, a DNA microarray analysis of the transcripts from R1 was performed, comparing cells grown in the presence or absence of novobiocin.