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Musashi1 contributes to glioblastoma development via regulation of a network of DNA replication, cell cycle, and division genes

ABSTRACT: Musashi1 contributes to glioblastoma development via regulation of a network of DNA replication, cell cycle, and division genes

PROVIDER: PRJNA634910 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11843759.fastq.gz	Fastqsanger.gz
	SRR11843760.fastq.gz	Fastqsanger.gz
	SRR11843761.fastq.gz	Fastqsanger.gz
	SRR11843762.fastq.gz	Fastqsanger.gz
	SRR11843763.fastq.gz	Fastqsanger.gz

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Musashi1 contributes to glioblastoma development via regulation of a network of DNA replication, cell cycle, and division genes

Project description:RNA binding proteins (RBPs) function as master regulators of gene expression. Alterations in their expression levels and function are often observed in tumors with numerous oncogenic RBPs identified in recent years. Musashi1 (Msi1) is an RBP and stem cell marker gene that controls the balance between self-renewal and proliferation. High Msi1 levels have been observed in multiple tumor types including glioblastoma and are often associated with poor patient outcomes. Msi1 knockdown is known to affect numerous cancer phenotypes and to prevent growth of different tumor types. To dissect Msi1’s main contributions to glioblastoma development, we conducted a comprehensive genomic analysis. We identified a network of cell cycle/division and DNA replication genes and established these processes as its core functions. Msi1 controls this gene network via two mechanisms: direct interaction and indirect regulation mediated by the transcription factors E2F2 and E2F8. We corroborated Msi1’s impact on these processes and determined that glioblastoma lines with Msi1 KO display increased sensitivity to cell cycle and DNA replication inhibitors. As Msi1 inhibitors have been identified, a drug combination strategy (Msi1 + cell cycle/DNA replication inhibitors) could be a viable route to treat glioblastoma.

2020-07-08 | GSE151155 | GEO

The RNA-binding protein Musashi1 is a central regulator of adhesion pathways in glioblastoma

Project description:The conserved RNA-binding protein Musashi1 (MSI1) has emerged as a key oncogenic factor in numerous solid tumors, including glioblastoma. However, its mechanism of action has not yet been established comprehensively. We set out to map its impact on the transcriptome in U251 cells using RNA-seq and iCLIP. Examination of gene expression and splicing changes upon KD of Musashi1 in U251 cells and link to iCLIP-identified Musashi1 RNA binding sites

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The RNA-binding protein Musashi1 is a central regulator of adhesion pathways in glioblastoma

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Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes.

Project description:RNA-binding proteins (RBPs) function as master regulators of gene expression. Alterations in their levels are often observed in tumors with numerous oncogenic RBPs identified in recent years. Musashi1 (Msi1) is an RBP and stem cell gene that controls the balance between self-renewal and differentiation. High Msi1 levels have been observed in multiple tumors including glioblastoma and are often associated with poor patient outcomes and tumor growth. A comprehensive genomic analysis identified a network of cell cycle/division and DNA replication genes and established these processes as Msi1's core regulatory functions in glioblastoma. Msi1 controls this gene network via two mechanisms: direct interaction and indirect regulation mediated by the transcription factors E2F2 and E2F8. Moreover, glioblastoma lines with Msi1 knockout (KO) displayed increased sensitivity to cell cycle and DNA replication inhibitors. Our results suggest that a drug combination strategy (Msi1 + cell cycle/DNA replication inhibitors) could be a viable route to treat glioblastoma.

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A mouse model of targeted Musashi1 expression in whole intestinal epithelium unveils its major roles in cell cycle and stemness

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