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Transcriptome analysis of normal oral cells and oral cancer cells treated with elemental diet (ED) Elental®

ABSTRACT: Transcriptome analysis of normal oral cells and oral cancer cells treated with elemental diet (ED) Elental®

PROVIDER: PRJNA635799 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11873689.fastq.gz	Fastqsanger.gz
	SRR11873690.fastq.gz	Fastqsanger.gz
	SRR11873691.fastq.gz	Fastqsanger.gz
	SRR11873692.fastq.gz	Fastqsanger.gz
	SRR11873693.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of normal oral cells and oral cancer cells treated with elemental diet (ED) Elental®

Project description:Purpose: Previously, we have reported the effectiveness of elemental diet (ED) Elental® against radiotherapy- or chemoradiotherapy- induced oral mucositis (Support Care Cancer 2016, Mol Clin Oncol 2019). However, administration of additional nutrition or ED in oral cancer patients might also provide extra nutrition for cancer cells, which could result in cancer development. At present, it is still unclear whether the beneficial effect of ED can be expected to surpass its possible harmful effect on oral cancer treatment. In the present study, we tried to clarify whether Elental® has different effects on human oral keratinocyte (HOK) cells compared to oral squamous cell carcinoma (OSCC) cells (HSC2). Method: Gene expression profiles of HOK cells and HSC2 cells treated with Elental® were generated by deep sequencing. Results: Whole transcriptome analysis data suggested that Elental® helped in the proliferation and survival of HOK through the induction of ERK. Moreover, Elental® added stress to HSC2 through the induction of endoplasmic reticulum stress response marker, BiP. Our results showed that Elental® might add stress to HSC2, and provide growth stimulation to HOK. Conclusion: Whole transcriptome analysis showed different gene expression profile between HOK cells and HSC2 cells treated with Elental®, suggesting that effects of Elental® might differ between normal oral cells and oral cancer cells.

2021-07-31 | GSE151420 | GEO

An elemental diet protects mouse salivary glands from 5-fluorouracil-induced atrophy.

Project description:In cancer patients, an elemental diet (ED) reduces adverse effects of chemotherapy, including oral mucositis. However, the detailed mechanism(s) of the healing effects of an ED remains unclear. In this study, the protective effects of the ED, Elental®, were examined against 5-fluorouracil (5-FU)-induced oral mucositis and salivary gland atrophy in mice. Mucositis was induced in female ICR mice by injection of 5-FU. The mice were orally administered Elental® (ED group) or saline (control group). After treatment, whole transcriptome analysis and network analysis were conducted to understand the mechanism(s) of action of Elental® against oral mucositis. Whole transcriptome analysis and Ingenuity Pathways Analysis (IPA) data suggested that Elental® contributed to the recovery of mitochondrial function in 5-FU-damaged salivary glands.

2022-05-05 | GSE196407 | GEO

EDMONd - Elemental Diet in Bowel Obstruction

Project description:A feasibility study to provide ‘proof of concept’ of Elemental Diet (ED) as an acceptable/ useful feeding option for patient with inoperable malignant bowel obstruction and to examine the impact of ED on quality of life

| 2244212 | ecrin-mdr-crc

ED Gut

Project description:ED Gut

| PRJEB45090 | ENA

RNAseq data comparing iKPC cells overexpressing WT-USP21 and ED-USP21

Project description:USP21 belongs to ubiquitin specific protease (USP) family. To dissect the molecular mechanisms that regulated by USP21 overexpression in PDAC cells, we conducted RNA-seq analysis of iKPC PDAC cells overexpressing wild-type USP21 (WT-USP21) and enzyme dead USP21 (ED-USP21).

2019-09-04 | GSE134686 | GEO

Aliarcobacter butzleri ED-1

Project description:Aliarcobacter butzleri ED-1 Genome sequencing

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Hypsibius dujardini strain:ED

Project description:Hypsibius dujardini strain:ED Genome sequencing

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Diaphorobacter sp. ED-3

Project description:Diaphorobacter sp. ED-3 Genome sequencing and assembly

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RNAseq data comparing iKPC cells overexpressing WT-USP21 and ED-USP21

Project description:RNAseq data comparing iKPC cells overexpressing WT-USP21 and ED-USP21