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Gene expression signatures in human B lymphoma cell line VAL

ABSTRACT: Gene expression signatures in human B lymphoma cell line VAL

PROVIDER: PRJNA639560 | ENA |

REPOSITORIES: ENA

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Gene expression signatures in human B lymphoma cell line VAL

Project description:To investigate the effect of PD-1 expression on gene expression, we have employed whole genome microarray expression profiling as a discovery platform to identify genes related to the cell proliferation of human B-cell lymphoma (HBCL) cell line VAL in vitro.

2020-06-16 | GSE152509 | GEO

Gene expression signatures for FGFR1 Knockdown in Mantle cell lymphoma cell line (Z-138)

Project description:Gene expression signatures for FGFR1 Knockdown in Mantle cell lymphoma cell line (Z-138)

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ACKR3 promotes CXCL12/CXCR4-mediated migration of lymphoma cells

Project description:Chemotaxis is an essential physiological process, often harnessed by tumors for metastasis. CXCR4, its ligand CXCL12 and the atypical receptor ACKR3 are overexpressed in many human cancers. Interfering with this axis by ACKR3 deletion impairs lymphoma cell migration towards CXCL12. Here, we propose a model of how ACKR3 controls the migration of the diffused large B-cell lymphoma VAL cells in vitro and in vivo in response to CXCL12. VAL cells expressing full-length ACKR3, but not a truncated version missing the C-terminus, can support the migration of VAL cells lacking ACKR3 (VAL-ko) when allowed to migrate together. This migration of VAL-ko cells is pertussis toxin-sensitive suggesting the involvement of a Gi-protein coupled receptor. RNAseq analysis indicate the expression of chemotaxis-mediating LTB4 receptors in VAL cells. We found that LTB4 acts synergistically with CXCL12 in stimulating the migration of VAL cells. Pharmacologic or genetic inhibition of BLT1R markedly reduces chemotaxis towards CXCL12 suggesting that LTB4 enhances in a contact-independent manner the migration of lymphoma cells. The results unveil a novel mechanism of cell-to-cell-induced migration of lymphoma.

2022-10-13 | GSE169144 | GEO

Analysis of gene expression signatures for primary vitreo retinal lymphoma

Project description:Analysis of gene expression signatures for primary vitreo retinal lymphoma

| PRJNA525342 | ENA

RNA-seq of HEK 293T cells treated with Val-boroPro

Project description:We report the application of RNA-seq for profiling gene transcription upon treatment of dipeptidyl peptidases 8 and 9 inhibitor, Val-boroPro (VbP). We find no significant changes in gene transcription upon treatment of mammalian cells with Val-boroPro.

2020-09-23 | GSE153744 | GEO

BATF3siRNA induced gene expression changes in Hodgkin lymphoma cell line L428.

Project description:In this study, we investigated the effect of BATF3 silecing on gene expression in Hodgkin lymphoma cell line L428.

2017-09-11 | GSE89760 | GEO

LY294002 induced gene expression changes in Hodgkin lymphoma cell line KMH2.

Project description:In this study, we investigated the effect of LY294002 on gene expression in Hodgkin lymphoma cell line KMH2 cells.

2017-09-11 | GSE89759 | GEO

tRF-Val-TAC-004 protects against renal ischemia-reperfusion injury via attenuating Apaf1-mediated apoptosis

Project description:tRNA-derived fragments (tRFs) play critical roles in cellular process, and we have previously reported that tRFs are involved in ischemia reperfusion injury induced acute kidney injury (IRI-AKI). However, the precise involvement of tRFs in IRI-AKI remains obscure. This study aims to elucidate the impact of tRF-Val-TAC-004 (tRF-Val) on IRI-AKI and uncover the underlying mechanisms. Our observations reveal a significant downregulation of tRF-Val in IRI-AKI mice and its overexpression mitigated renal dysfunction, morphological damage, and apoptosis in IRI-AKI mice, while its inhibition exacerbated these effects. Similar outcomes were replicated in CoCl2-treated BUMPT cells upon transfection with tRF-Val mimic or inhibitor. Mechanistically, dual-luciferase reporter assay and AGO-RIP qPCR analyses demonstrated that tRF-Val suppresses Apaf1 expression by targeting the 3’-UTR of Apaf1 mRNA. Furthermore, the protective efficacy of tRF-Val was notably weakened by Apaf1-overexpressing plasmids. In summary, these novel findings unveil the protective role of tRF-Val against IRI-AKI through inhibition of Apaf1-mediated apoptosis.

2024-12-18 | GSE282997 | GEO

Transcriptional Profiling Identifies Prognostic Gene Signatures for Conjunctival Lymphoma

Project description:Transcriptional Profiling Identifies Prognostic Gene Signatures for Conjunctival Lymphoma

| PRJNA904693 | ENA

Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma

Project description:Peripheral T-cell lymphoma (PTCL) encompasses a heterogeneous group of neoplasms with generally poor clinical outcome. Currently 50% of PTCL cases are not classifiable: PTCL-not otherwise specified (NOS). Gene-expression profiles on 372 PTCL cases were analyzed and robust molecular classifiers and oncogenic pathways that reflect the pathobiology of tumor cells and their microenvironment were identified for major PTCL-entities, including 114 angioimmunoblastic T-cell lymphoma (AITL), 31 anaplastic lymphoma kinase (ALK)-positive and 48 ALK-negative anaplastic large cell lymphoma, 14 adult T-cell leukemia/lymphoma and 44 extranodal NK/T-cell lymphoma that were further separated into NK-cell and gdT-cell lymphomas. Thirty-seven percent of morphologically diagnosed PTCL-NOS cases were reclassified into other specific subtypes by molecular signatures. Reexamination, immunohistochemistry, and IDH2 mutation analysis in reclassified cases supported the validity of the reclassification. Two major molecular subgroups can be identified in the remaining PTCL-NOS cases characterized by high expression of either GATA3 (33%; 40/121) or TBX21 (49%; 59/121). The GATA3 subgroup was significantly associated with poor overall survival (P=.01). High expression of cytotoxic genesignaturewithin the TBX21 subgroup also showed poor clinical outcome (P=.05). InAITL, high expression of several signatures associated with the tumor microenvironment was significantly associated with outcome. A combined prognostic score was predictive of survival in an independent cohort (P=.004).

2015-06-01 | GSE58445 | GEO

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