Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Clustering of strong replicators associated with active promoters is sufficient to establish an early-replicating domain

ABSTRACT: Clustering of strong replicators associated with active promoters is sufficient to establish an early-replicating domain

PROVIDER: PRJNA643249 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12120500_1.fastq.gz	Fastqsanger.gz
	SRR12120500_2.fastq.gz	Fastqsanger.gz
	SRR12120501_1.fastq.gz	Fastqsanger.gz
	SRR12120501_2.fastq.gz	Fastqsanger.gz
	SRR12120502_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 88

Similar Datasets

Clustering of strong replicators associated with active promoters is sufficient to establish an early-replicating domain

Project description:Clustering of strong replicators associated with active promoter are sufficient to establish an early-replicating domain

2020-09-07 | GSE153566 | GEO

Clustering of strong replicators associated with active promoters is sufficient to establish an early-replicating domain.

Project description:Vertebrate genomes replicate according to a precise temporal program strongly correlated with their organization into A/B compartments. Until now, the molecular mechanisms underlying the establishment of early-replicating domains remain largely unknown. We defined two minimal cis-element modules containing a strong replication origin and chromatin modifier binding sites capable of shifting a targeted mid-late-replicating region for earlier replication. The two origins overlap with a constitutive or a silent tissue-specific promoter. When inserted side-by-side, these modules advance replication timing over a 250 kb region through the cooperation with one endogenous origin located 30 kb away. Moreover, when inserted at two chromosomal sites separated by 30 kb, these two modules come into close physical proximity and form an early-replicating domain establishing more contacts with active A compartments. The synergy depends on the presence of the active promoter/origin. Our results show that clustering of strong origins located at active promoters can establish early-replicating domains.

| S-EPMC7604622 | biostudies-literature

Foxa2 overexpression is sufficient to establish the p3 neural progenitor chromatin landscape

Project description:Foxa2 overexpression is sufficient to establish the p3 neural progenitor chromatin landscape

| PRJNA841845 | ENA

IDH1 Mutation is a Master Regulator of Epigenomic Remodeling and is Sufficient to Establish the Glioma Hypermethylator Phenotype

Project description:IDH1 Mutation is a Master Regulator of Epigenomic Remodeling and is Sufficient to Establish the Glioma Hypermethylator Phenotype

| PRJNA143653 | ENA

Extracellular vesicles secreted from HBV-replicating or non-replicating cells

Project description:LC/MS proteomic analysis of EVs secreted from HBV-replicating or non-replicating cells was performed.

2020-08-14 | PXD018292 | JPOST Repository

G9a selectively represses a class of late-replicating genes at the nuclear periphery (Expression)

Project description:We have investigated the role of the histone methyltransferase G9a in the establishment of silent nuclear compartments. Following conditional knockout of the G9a methyltransferase in mouse ESCs, 167 genes were significantly up-regulated, and no genes were strongly down-regulated. A partially overlapping set of 119 genes were up-regulated after differentiation of G9a-depleted cells to neural precursors. Promoters of these G9a-repressed genes were AT rich and H3K9me2 enriched but H3K4me3 depleted and were not highly DNA methylated. Representative genes were found to be close to the nuclear periphery, which was significantly enriched for G9a-dependent H3K9me2. Strikingly, although 73% of total genes were early replicating, more than 71% of G9a-repressed genes were late replicating, and a strong correlation was found between H3K9me2 and late replication. However, G9a loss did not significantly affect subnuclear position or replication timing of any non-pericentric regions of the genome, nor did it affect programmed changes in replication timing that accompany differentiation. We conclude that G9a is a gatekeeper for a specific set of genes localized within the late replicating nuclear periphery. 4 cell states each in duplicate (i.e. a total of 8 individual replicates)

2010-06-20 | E-GEOD-18076 | biostudies-arrayexpress

G9a selectively represses a class of late-replicating genes at the nuclear periphery (WG_CGH)

2009-11-02 | E-GEOD-18079 | biostudies-arrayexpress

G9a selectively represses a class of late-replicating genes at the nuclear periphery (WG_CGH)

2009-11-03 | GSE18079 | GEO

G9a selectively represses a class of late-replicating genes at the nuclear periphery (Expression)

2009-11-03 | GSE18076 | GEO

Purification of replicating pancreatic β-cells for gene expression studies

Project description:β-cell proliferation is a rare event in adult pancreatic islets. To study the replication-related β-cell biology we designed a replicating β-cells sorting system based on EdU incorporation for gene expression experiments. The global transcriptome of replicating and quiescent pancreatic β-cells was analysed using gene expression arrays.

2017-12-13 | GSE104387 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data