Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (ChIP-Seq)

ABSTRACT: Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (ChIP-Seq)

PROVIDER: PRJNA644364 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12157811.fastq.gz	Fastqsanger.gz
	SRR12157812.fastq.gz	Fastqsanger.gz
	SRR12157813.fastq.gz	Fastqsanger.gz
	SRR12157814.fastq.gz	Fastqsanger.gz
	SRR12157815.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 18

Similar Datasets

Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance

Project description:Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance

| PRJNA644368 | ENA

Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (RNA-Seq)

Project description:Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (RNA-Seq)

| PRJNA644371 | ENA

Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (ATAC-Seq)

Project description:Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (ATAC-Seq)

| PRJNA644365 | ENA

Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (DNAse I hypersensitivity)

Project description:Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (DNAse I hypersensitivity)

| PRJNA644366 | ENA

Wilms' tumor 1 WT1(-KTS) isoform time course induction in U2OS cells

Project description:The Wilms' tumor suppressor gene (WT1) encodes a zinc finger transcription factor that plays important roles during development of several organs including metanephric kidneys. A number of WT1 target genes have been identified, but the detailed mechanisms by which WT1 orchestrates renal development remain elusive. To identify WT1 target genes relevant to development, genome-wide expression profiling was performed using oligonucleotide microarrays representing 39,000 human transcripts Keywords: Wilms' tumor 1 (WT1) gene, -KTS isoform; time course

2007-06-21 | GSE5117 | GEO

Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (RNA-Seq)

Project description:Acute myeloid leukemia (AML) is caused by recurrent mutations in members of the gene regulatory and signalling machinery subverting hematopoietic differentiation. We previously showed that each AML sub-type displays a different gene regulatory network with specific transcription factor families playing distinct roles in maintaining the leukemic phenotype. Here we show that the transcription factor WT1 forms a major node in the gene regulatory networks of multiple AML sub-types. It is frequently mutated and up-regulated in AML and its expression is pedictive for relapse. The WT1 protein exists as different isoforms which we show here to harbor differential chromatin binding and contrasting biological activity, including directing differential splicing. For two main AML subtypes we demonstrate that WT1 responds to oncogenic signaling and is part of a signaling-responsive transcription factor hub that controls AML growth. WT1 therefore plays a central and wide-spread role in AML biology.

2021-07-30 | GSE153864 | GEO

Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (ChIP-Seq)

2021-07-30 | GSE153861 | GEO

Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (ATAC-Seq)

2021-07-30 | GSE153860 | GEO

Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance (DNAse I hypersensitivity)

2021-07-30 | GSE153863 | GEO

Isoform- and mutation- specific roles of Wilms Tumor 1 in acute myeloid leukemia maintenance

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-07-30 | GSE153865 | GEO