Project description:To understand the molecular basis of the acquisition of 5-FU resistance in gastric cancer stem cells, we established 5-FU-resistant gastric cancer organoids. We used microarrays to detail the global program of gene expression underlying 5-FU resistance and maintenance of stem cell properties in gastric cancer.
Project description:To study Aqp5 functions in human gastric cancer organoids, we generated Aqp5 FLIP-Puro organoids allowing for inducible loss of Aqp5 expression upon Cre gesicle administration. We analysed transcriptomes of these organoids at various timepoints following loss of Aqp5 to elucidate potential functions of Aqp5 in this system.
Project description:In this dataset, we include the expression data obtained from gastric cancer tissues and gastric normal tissues to determine the differentially expressed genes in gastric cancer tissues.
Project description:In this dataset, we include the expression data obtained from gastric cancer tissues and gastric normal tissues to determine the differentially expressed genes in gastric cancer tissues
Project description:Gastric cancer is a most prevalent cancer with high mortality and strong invasiveness. Presently, there are many kinds of diagnosis and treatment methods, but the diagnosis rate of early gastric cancer is still not high, with a low five-year survival rate. Although the gastric cancer mechanism has been extensively studied, but the entire regulatory networks of gastric cancer is still unclear. We used microarrays to detect gene expression in NOL6 normal and knockdown gastric cancer cells a, and to identify differentially expressed genes in this program.