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ScRNA-seq studies

ABSTRACT: scRNA-seq studies

PROVIDER: PRJNA648132 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR12299417.fastq.gz	Fastqsanger.gz
	SRR12299418.fastq.gz	Fastqsanger.gz
	SRR12299419.fastq.gz	Fastqsanger.gz
	SRR12299420.fastq.gz	Fastqsanger.gz

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1 - 5 of 13

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RNA-seq studies

Project description:RNA-seq studies

| PRJNA704569 | ENA

Single cell RNA-seq analysis links respiratory dysfunction to an extracellular matrix-specific damage response

Project description:Energy metabolism and extracellular matrix function are closely connected to orchestrate and maintain tissue organization, but the crosstalk is poorly understood. Here, we used scRNA-seq analysis to uncover the importance of respiration for extracellular matrix homeostasis in mature cartilage. Genetic inhibition of respiration in cartilage results in the expansion of a central area of 1-month-old mouse femur head cartilage showing disorganized chondrocytes and increased deposition of extracellular matrix material. scRNA-seq analysis identified a cluster-specific decrease in mitochondrial DNA-encoded respiratory chain genes and a unique regulation of extracellular matrix-related genes in nonarticular chondrocyte clusters. These changes were associated with alterations in extracellular matrix composition, a shift in the collagen/non-collagen protein content and an increase of collagen crosslinking and ECM stiffness. The results demonstrate, based on findings of the scRNA-seq analysis, that respiration is a key factor contributing to ECM integrity and mechanostability in cartilage and presumably also in many other tissues.

2022-02-17 | PXD027109 | Pride

scRNA-seq data of mouse splenocytes

Project description:We generated scRNA-seq data of mouse spenocytes that correspond to a previously published scATA-seq data.

2021-11-30 | E-MTAB-9769 | biostudies-arrayexpress

RNA sequencing/Gene expression studies of G⍺13 signaling in lymphoma [scRNA-seq]

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Inferring TF activation order in time series scRNA-Seq studies.

Project description: Not available

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Project description:HSPC scRNA seq

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Village In a Dish: A Model System for Population-scale hiPSC Studies [scRNA-Seq]

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scRNA-seq

Project description:scRNA-seq

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scRNA-seq of pluripotent stem cell derived human intestinal organoids

Project description:Here, we used single cell RNA-sequencing (scRNA-seq) to profile pluripotent stem cell derived human intestinal organoids (HIOs) grown in matrigel or a non-adhesive alginate hydrogel after 28 days of in vitro growth. Additionally, we used scRNA-seq to profile HIOs derived in the presence of Neuregulin 1 (NRG1) and/or EGF after 40 days of in vitro growth.

2021-05-21 | E-MTAB-10268 | biostudies-arrayexpress

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