Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Klebsiella pneumoniae

ABSTRACT: WGS based Study on Carbapenem-Resistant KPC-2 producing Klebsiella pneumoniae isolated from blood of sepsis patients admitted to tertiary care hospitals in Kolkata, India

PROVIDER: PRJNA649689 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other
	SRR14289771_1.fastq.gz	Fastqsanger.gz
	SRR19134895_1.fastq.gz	Fastqsanger.gz
	SRR33235337_1.fastq.gz	Fastqsanger.gz
	SRR33235337_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 75

Similar Datasets

Klebsiella pneumoniae

Project description:Oxa48 like carbapenemase-producing Klebsiella pneumoniae isolated from blood of sepsis patients admitted to tertiary care hospitals in kolkata,India.

| PRJNA723764 | ENA

Proteus mirabilis

Project description:Study on Carbapenem-resistant Proteus mirabilis isolated from the blood of sepsis patients admitted in tertiary care hospitals in Kolkata,India

| PRJNA662829 | ENA

Serratia ureilytica strain:FTCR59

Project description:Studies on WGS of Carbapenem Resistant Serratia sp. isolated from the blood of sepsis patients admitted to tertiary care hospitals in Kolkata, India

| PRJNA662834 | ENA

Enterobacter

Project description:Study on blood-borne Carbapenem-resistant Enterobacter cloacae complex isolated from sepsis patients admitted to ICU departments of tertiary care hospitals at Kolkata,India.

| PRJNA721536 | ENA

Clinical Evaluation of Advanced MALDI-TOF MS for Carbapenemase Subtyping in Gram-negative Isolates

Project description:The spread of carbapenemase-producing Enterobacterales (CPE) is emerging as a significant clinical concern in tertiary hospitals and in particular, long-term care facilities with deficiencies in infection control. This study aims to evaluate an advanced matrix-assisted laser desorption/ionization mass spectrometry (A-MALDI) method for the identification of carbapenemases and further discrimination of their subtypes in clinical isolates. The A-MALDI method was employed to detect CPE target proteins. Enhancements were made to improve detectability and mass accuracy through the optimization of MALDI-TOF settings and internal mass calibration. A total of 581 clinical isolates were analyzed, including 469 CPE isolates (388 KPC, 51 NDM, 40 OXA, and 2 GES) and 112 carbapenemase-negative isolates. Clinical evaluation of the A-MALDI demonstrated 100% accuracy and precision in identifying all the collected CPE isolates. Additionally, A-MALDI successfully discriminated individual carbapenemase subtypes (KPC-2 or KPC-3/4; OXA-48 or OXA-181 or OXA-232; GES-5 or GES-24) and also differentiated co-producing carbapenemase strains (KPC & NDM; KPC & OXA; KPC & GES; NDM & OXA), attributed to its high mass accuracy and simultaneous detection capability. A-MALDI is considered a valuable diagnostic tool for accurately identifying CPE and carbapenemase’s subtypes in clinical isolates. It may also aid in selecting appropriate antibiotics for each carbapenemase subtype. Ultimately, we expect that the A-MALDI method will contribute to preventing the spread of antibiotic resistance and improving human public health.

2024-11-26 | PXD058284 | Pride

Genomic landscape of the individual host response and outcomes in severe sepsis revealed by transcriptomic profiling and quantitative trait mapping (derivation cohort)

Project description:We assayed leukocyte global gene expression for a prospective discovery cohort of 265 adult patients admitted to UK intensive care units with severe sepsis due to community acquired pneumonia.

2016-02-25 | E-MTAB-4421 | biostudies-arrayexpress

Genomic landscape of the individual host response and outcomes in severe sepsis revealed by transcriptomic profiling and quantitative trait mapping (validation cohort)

Project description:We assayed leukocyte global gene expression for a prospective validation cohort of 106 adult patients admitted to UK intensive care units with severe sepsis due to community acquired pneumonia.

2016-02-25 | E-MTAB-4451 | biostudies-arrayexpress

Microarray transcriptomic profiling of patients with sepsis due to faecal peritonitis and pneumonia to identify shared and distinct aspects of the transcriptomic response (validation cohort)

Project description:We assayed leukocyte global gene expression for a prospective discovery cohort of 106 adult patients admitted to UK intensive care units with sepsis due to community acquired pneumonia or faecal peritonitis. We assigned all samples to sepsis response signature groups after performing unsupervised analysis of the transcriptomic data.

2017-05-01 | E-MTAB-5274 | biostudies-arrayexpress

Blood transcriptome of human sepsis in an Indian cohort [Illumina array]

Project description:Sepsis remains a lethal ailment with imprecise treatment and ill-understood biology. A clinical transcriptomic analysis of sepsis patients was performed for the first time in India and revealed large-scale change in blood gene expression in patients of severe sepsis and septic shock admitted to ICU. Three biological processes were quantified using scores derived from the corresponding transcriptional modules. Comparison of the module scores revealed that genes associated with immune response were more suppressed compared to the inflammation-associated genes. These findings will have great implication in the treatment and prognosis of severe sepsis/septic shock if translated into a bedside tool.

2022-09-12 | GSE137340 | GEO

Critically ill patients with either gram-positive sepsis or gram-negative sepsis

Project description:Objective: It is unclear whether the host response of gram-positive sepsis differs from gram-negative sepsis at a transcriptome level. Using microarray technology, we compared the gene-expression profiles of gram-positive sepsis and gram-negative sepsis in critically ill patients. Design: A prospective cross-sectional study. Setting: A 20-bed general intensive care unit of a tertiary referral hospital. Patients: Seventy-two patients admitted to the intensive care unit. Interventions: Intravenous blood was collected for leukocyte separation and RNA extraction. Microarray experiements were then performed examing the expression level of 19,232 genes in each sample. Measurements and Main Results: There was no difference in the expression profile between gram-positive and gram-negative sepsis. The finding remained unchanged even when genes with lower expression level were included or after statistical stringency was lowered. There were, however, ninety-four genes differentially expressed between sepsis and control patients. These genes included those involved in immune regulation, inflammation and mitochondrial function. Hierarchical cluster analysis confirmed that the difference in gene expression profile existed between sepsis and control patients, but not between gram-positive and gram-negative patients. Conclusion: Gram-positive and gram-negative sepsis share a common host response at a transcriptome level. These findings support the hypothesis that the septic response is non-specific and is designed to provide a more general response that can be elicited by a wide range of different micro-organisms. Keywords: disease state analysis, gram-positive sepsis, gram-negative sepsis

2007-12-01 | GSE6535 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data