Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions [w5C6]

ABSTRACT: Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions [w5C6]

PROVIDER: PRJNA649805 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12356816.fastq.gz	Fastqsanger.gz
	SRR12356817.fastq.gz	Fastqsanger.gz
	SRR12356818.fastq.gz	Fastqsanger.gz
	SRR12356819.fastq.gz	Fastqsanger.gz
	SRR12356820.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions

Project description:Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions

| PRJNA649800 | ENA

Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions [an3]

Project description:Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions [an3]

| PRJNA649798 | ENA

Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-12-31 | GSE155464 | GEO

Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions [w5C6]

Project description:We performed a transcriptome analysis on FACS-sorted GFP positive cells from pCYCD6;1-GFP, wox5xpCYCD6;1-GFP, and pWOX5-GFP, and the GFP negative cells from pWOX5-GFP to obtain CEI specific transcriptional profiles in a WT and in a wox5 mutant background.

2020-12-31 | GSE155463 | GEO

Exchange of molecular and cellular information: a hybrid model that integrates stem cell divisions and key regulatory interactions [an3]

Project description:We performed a transcriptome analysis on the meristematic root tissue from the loss-of-function line an3 and WT plants.

2020-12-31 | GSE155462 | GEO

AACR Project Genomics Evidence Neoplasia Information Exchange (GENIE)

Project description:AACR Project Genomics Evidence Neoplasia Information Exchange (GENIE)

| PRJNA380293 | ENA

Memory of cell divisions directs the continuous process of primitive hematopoietic lineage commitment

Project description:Hematopoietic stem cells (HSCs) exist in a dormant state, and progressively lose regenerative potency as they undergo successive divisions. Why this functional decline occurs and how this information is encoded is unclear. To better understand how this information is stored, we performed RNA sequencing on HSC populations differing only in their divisional history. Comparative analysis revealed that genes upregulated with divisions are enriched for lineage commitment factors, and are regulated by cell cycle-associated transcription factors, indicating that proliferation itself drives primitive hematopoietic lineage priming. In contrast, downregulated genes are associated with an HSC signature and are targeted by the Polycomb Repressive Complex 2 (PRC2). We find that Ezh2 targets HSC signature genes for repression, and a divisional history-dependent switch from Ezh1 to Ezh2 underlies HSC decline with progressive divisions. Thus cell divisions drive lineage priming and Ezh2 accumulation, which represses HSC signature genes and consolidates information on divisional history into memory.

2020-03-14 | GSE145772 | GEO

Regulators of histone exchange

Project description:Regulators of histone exchange

| PRJNA927495 | ENA

Composting biotechnology information

Project description:Composting biotechnology information Genome sequencing

| PRJNA1060420 | ENA

Asymmetric Segregation of the Nucleosome Remodeling and Deacetylase Complex during Asymmetric Cell Divisions

Project description:Asymmetric cell divisions (ACDs) generate two daughter cells with identical genetic information but distinct cell fates. Epigenetic mechanisms are crucial for cell fate specification, and it remains unclear how epigenetic information is inherited. Here, we report asymmetric segregation of the nucleosome remodeling and deacetylase complex (NuRD) during ACDs in Caenorhabditis elegans. NuRD is enriched to chromosomes of the future surviving but not apoptotic daughter cell, whereas NuRD evenly distributes to two viable siblings. Disruption of ACDs causes symmetric NuRD inheritance, and an ectopic gain of NuRD in apoptotic daughters allows cell survival and differentiation. Lack of NuRD upregulates the expression of the vital cell death-inducing gene egl-1 by increasing H3K27 acetylation on the egl-1 locus, which activates the EGL-1-CED-9-CED-4-CED-3 pathway to promote apoptosis. We propose that biased NuRD segregation during ACDs provides a previously unrecognized yet common mechanism for asymmetrically partitioning epigenetic information that contributes to binary cell fate decisions.

2022-12-30 | GSE167379 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data