Project description:We sought to determine how a cystic fibrosis isolate of Stenotrophomonas maltophilia responds to relevant pH gradients (pH 5, 7, and 9) by growing the bacterium in phosphate buffered media and conducting RNAseq experiments. Our data suggests acidic conditions are stressful for strain FLR19, as it responded by increasing expression of stress-response and antibiotic-resistance genes.
Project description:In this project, the impact of subinhibitory concentrations of the fluoroquinolone ciprofloxacin on the multiresistant bacterium Stenotrophomonas maltophilia (strain LMG 26824) has been investigated. A label free proteomics analysis was performed to analyse the proteome of cells incubated with ciprofloxacin compared to a control sample.