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ELL facilitates RNA Polymerase II mediated transcription of human epidermal proliferation genes

ABSTRACT: ELL facilitates RNA Polymerase II mediated transcription of human epidermal proliferation genes

PROVIDER: PRJNA655182 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12384500_1.fastq.gz	Fastqsanger.gz
	SRR12384500_2.fastq.gz	Fastqsanger.gz
	SRR12384501_1.fastq.gz	Fastqsanger.gz
	SRR12384501_2.fastq.gz	Fastqsanger.gz
	SRR12384502.fastq.gz	Fastqsanger.gz

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ELL facilitates RNA Polymerase II mediated transcription of human epidermal proliferation genes

Project description:ELL plays an essential role in human epidermal proliferation by binding to proliferation genes and facilitating the stabilization of RNA Polymerase II at the TSS to sustain their gene expression

2020-12-22 | GSE155667 | GEO

ELL Facilitates RNA Polymerase II-Mediated Transcription of Human Epidermal Proliferation Genes.

Project description: Not available

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CDK12 maintains phosphorylation of RNA Polymerase II during epidermal differentiation

Project description:CDK12 plays an important role in regulating epidermal differntaition through maintaining the phosphorylation of RNA polymerase II levels in differentiation associated genes.

2024-02-08 | GSE166407 | GEO

CDK12 maintains phosphorylation of RNA Polymerase II during epidermal differentiation

Project description:CDK12 maintains phosphorylation of RNA Polymerase II during epidermal differentiation

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High proliferation and delamination during skin epidermal stratification

Project description:High proliferation and delamination during skin epidermal stratification

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Vitamin C promotes epidermal proliferation by enhancing the DNA demethylation of proliferation-related genes in human epidermal equivalents (Microarray)

Project description:Vitamin C promotes epidermal proliferation by enhancing the DNA demethylation of proliferation-related genes in human epidermal equivalents (Microarray)

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Vitamin C promotes epidermal proliferation by enhancing the DNA demethylation of proliferation-related genes in human epidermal equivalents (WGBS)

Project description:Vitamin C promotes epidermal proliferation by enhancing the DNA demethylation of proliferation-related genes in human epidermal equivalents (WGBS)

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TEAD1 and TEAD3 play redundant roles in human epidermal proliferation

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Schizosaccharomyces pombe Pol II Transcription Elongation Factor ELL Functions as Part of a Rudimentary Super Elongation Complex

Project description:ELL family transcription factors activate the overall rate of RNA polymerase II (Pol II) transcription elongation by binding directly to Pol II and suppressing its tendency to pause. In metazoa, ELL regulates Pol II transcription elongation as part of a large multisubunit complex referred to as the Super Elongation Complex (SEC), which includes P-TEFb and EAF, AF9 or ENL, and an AFF family protein. Although orthologs of ELL and EAF have been identified in lower eukaryotes including S. pombe, it has been unclear whether SEC-like complexes function in lower eukaryotes. In this report, we describe isolation from S. pombe of an ELL-containing complex with features of a rudimentary SEC. This complex includes S. pombe Ell1, Eaf1, and a previously uncharacterized protein we designate Ell1 binding protein 1 (Ebp1), which is distantly related to metazoan AFF family members. Like the metazoan SEC, this S. pombe ELL complex appears to function broadly in Pol II transcription. Interestingly, it appears to have a particularly important role in regulating genes involved in cell separation.

2018-07-26 | GSE115636 | GEO

High proliferation and delamination during skin epidermal stratification

Project description:The development of complex stratified epithelial barriers in mammals is initiated from single-layered epithelia. How stratification is initiated and fueled are still open questions. Previous studies on skin epidermal stratification suggested a central role for perpendicular/asymmetric cell division orientation of the basal keratinocyte progenitors. Here, we use centrosomes, that organize the mitotic spindle, to test whether cell division orientation and stratification are linked. Genetically ablating centrosomes from the developing epidermis leads to the activation of the p53-, 53BP1- and USP28-dependent mitotic surveillance pathway causing a thinner epidermis and hair follicle arrest. The centrosome/p53-double mutant keratinocyte progenitors significantly alter their division orientation in the later stages without majorly affecting epidermal differentiation. Together with time-lapse imaging and tissue growth dynamics measurements, the data suggest that the first and major phase of epidermal development is boosted by high proliferation rates in both basal and suprabasally-committed keratinocytes as well as cell delamination, whereas the second phase maybe uncoupled from the division orientation of the basal progenitors. The data provide insights for tissue homeostasis and hyperproliferative diseases that may recapitulate developmental programs.

2021-04-02 | GSE161387 | GEO

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