Project description:DKFZ-608 induces oxidative stress in the cytoplasm of treated cancer cell lines. The molecular reason for this is the inhibition of the cytoplamic thioredoxin reductase TRXR1. The EC50 of cytotoxicity differes substantialy in SCLC (hypersensitive) and NSCLC (resistant). The experiment aims to identify stress response pathways induced by the compound which could explain the cytotoxic activity of the compound and its differential effect.

2019-12-02 | GSE123340 | GEO

PARP inhibition induces cytotoxicity in mESCs by activating endogenous retroviruses.

Project description:PARP inhibition induces cytotoxicity in mESCs by activating endogenous retroviruses.

| PRJNA702474 | ENA

2-Phenylmaltol treatment induces cytotoxicity in human cancer cell lines.

Project description:Gene expression anlysis of 2-Phenylmaltol terted HeLa and HCT116 cells.

2021-08-05 | GSE155786 | GEO

GSK-J4 treatment in ovarian cancer cell lines (ATAC-Seq)

Project description:GSK-J4 treatment in ovarian cancer cell lines (ATAC-Seq)

| PRJNA1090516 | ENA

GSK-J4 treatment in ovarian cancer cell lines (RNA-Seq)

Project description:GSK-J4 treatment in ovarian cancer cell lines (RNA-Seq)