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Transcriptome analysis following Apigenin and Chrysin treatment of Mouse Embryonic Fibroblasts

ABSTRACT: Transcriptome analysis following Apigenin and Chrysin treatment of Mouse Embryonic Fibroblasts

PROVIDER: PRJNA655832 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12407348_1.fastq.gz	Fastqsanger.gz
	SRR12407348_2.fastq.gz	Fastqsanger.gz
	SRR12407349_1.fastq.gz	Fastqsanger.gz
	SRR12407349_2.fastq.gz	Fastqsanger.gz
	SRR12407350_1.fastq.gz	Fastqsanger.gz

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Transcriptome analysis following Apigenin and Chrysin treatment of Mouse Embryonic Fibroblasts

Project description:There is no known single therapeutic drug for treating hypercholesterolemia that comes with negligible systemic side effects. In the current study, using next generation RNA sequencing approach in mouse embryonic fibroblasts we discovered that two structurally related flavonoid compounds, Apigenin and Chrysin exhibited moderate blocking ability of multiple transcripts that regulate rate limiting enzymes in the cholesterol biosynthetic pathway. The observed decrease in cholesterol biosynthesis pathway correlated well with an increase in transcripts involved in generation and trafficking of ketone bodies as evident by the upregulation of Bdh1 and Slc16a6 transcripts. Impact statement - The hypocholesterolemic potential of Apigenin and Chrysin at higher concentrations along with their ability to generate ketogenic substrate especially during embryonic stage is useful or detrimental for embryonic health is not clear and still debatable. Our findings will set the stage for translating this information to whole animal and clinical studies that could shed light to the existing information regarding safe use of Apigenin and Chrysin, specifically to embryonic health.

2021-08-09 | GSE155852 | GEO

Mouse embryonic fibroblasts - transcriptional analysis following uracil treatment

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Differential gene expression in mice liver following apigenin administration

Project description:Differential gene expression in mice liver after apigenin administration. Gene expression from control mice were compared with apigenin treated mice at different dose level.

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Differential gene expression in mice liver following apigenin administration

Project description:Differential gene expression in mice liver after apigenin administration. Gene expression from control mice were compared with apigenin treated mice at different dose level. To study differential expression primarily at high stringency and in dose dependent manner was to increase the statistical confidence in the detection of important genes and cellular processes with a probable role in the initiation and propagation of toxicity as well as those possibly involved in regeneration during the early phase of tissue response.

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Metabolomics Workbench ST000003 - GNPS - Metabolomic analysis of mouse embryonic fibroblasts, embryonic stem cells, and induced pluripotent stem cells

Project description:mouse embryonic fibroblasts, embryonic stem cells, and induced pluripotent stem cells were compared via metabolomic analysis

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The transcriptome sequencing of Chrysin treated Scc9 Extracellular vesicles

Project description:EVs-Chrysin(Chrysin-treated SCC9) were isolated from SCC9 cells that were treated with chrysin. To improve the therapeutic effect, AuNPs were carried by EVs-Chrysin (Au-EVs). Compared to BGC823 and HCC-LM3 cells, the uptake of Au-EVs were specific in SCC9 cells. Moreover, Au-EVs combined with NIR enhanced cell apoptosis in TSCC cells. To confirm the role of miRNAs in cell apoptosis, the differentially expressed miRNAs between EVs-Con and EVs-Chrysin were screened by RNA-seq.

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The RNA-seq result of GC cells which were treated with chrysin

Project description:Chrysin has been reported to have anticancer effect. We used 40μM chrysin to treat SGC7901 cells for 48h, then sequenced their RNA, analyzed the differentially expressed genes before and after treatment, screened out the anticancer target of chrysin, and then carried on the next analysis

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Chrysin alleviates cardiomyocyte ferroptosis of diabetic cardiomyopathy by modulating SCD1

Project description:Our findings demonstrated that chrysin supplementation improved the impaired cardiac function in DCM mice and alleviated HG-induced damage in AC16 cells. Whole transcriptome sequencing analysis indicated that the cardioprotective effects of chrysin are closely associated with the inhibition of cardiomyocytes ferroptosis. Chrysin treatment attenuated elevated ferroptosis, as evidenced by reduced Fe2+ content and lipid peroxidation levels, enhanced antioxidant capacity and restored expression of SLC7A11 and GPX4.

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Project description:Expression profiling following Nrf2D29H or Keap1R554Q expression in mouse embryonic fibroblasts

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The effects of apigenin on microRNA expression levels

Project description:The changes of mature microRNA expression levels after apigenin treatment on Huh7 cells were determined. Huh7 cells were treated with 10microM apigenin for 24hr and the changes of global mature microRNA expression levels were determined.

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