Human stomach gastric cancer vs dysplasia
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA656072 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Non-tumor stomach tissue from gastric cancer patients.
2007-03-27 | E-SMDB-3964 | biostudies-arrayexpress
Project description:Gastric cancers account for the fourth most frequent cancer death worldwide. Although many differential gene expression profiles are reported for gastric cancers, their variation at the post-transcriptional level has not been provided yet. In this study, we compared the gene expressions of normal stomach vs. stomach cancer in an exon-wise manner and compared alternatively spliced transcripts. The RNA from normal and cancer tissues of gastric cancer patients were subjected to Exon 1.0 ST microarrays.
2014-07-12 | GSE30727 | GEO
Project description:Gastric cancers account for the fourth most frequent cancer death worldwide. Although many differential gene expression profiles are reported for gastric cancers, their variation at the post-transcriptional level has not been provided yet. In this study, we compared the gene expressions of normal stomach vs. stomach cancer in an exon-wise manner and compared alternatively spliced transcripts. The RNA from normal and cancer tissues of gastric cancer patients were subjected to Exon 1.0 ST microarrays. Transcriptome analysis of RNAs from normal and cancer tissues of human stomach by exon array. We analyzed 30 pairs of normal-cancer stomach tissues using the Affymetrix Human Exon 1.0 ST platform. Array data was processed by the Affymetrix Exon Array Computational Tool.
2014-07-12 | E-GEOD-30727 | biostudies-arrayexpress
Project description:MicroRNA (miRNA) expression profiles for gastric cancers were examined to investigate the miRNA involvement in stomach carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate stomach cancers from noncancerous stomach tissues.
2005-12-31 | E-TABM-50 | biostudies-arrayexpress
Project description:Gastric cancer (GC) is one of the most common malignant cancers in the world. c-Myc, a well-known oncogene, is commonly amplified in many cancers, including gastric cancer. However, it is still not completely understood how c-Myc functions in GC. Here, we generated a stomach-specific c-Myc knock-in mouse model to investigate its role in GC. We found that overexpression of c-Myc in Atp4b+ gastric parietal cells could induce intestinal-type gastric cancer in mice. Mechanistically, c-Myc promoted tumorigenesis via the AKT/mTOR pathway. Furthermore, AKT inhibitor (MK-2206) or mTOR inhibitor (Rapamycin) inhibited the proliferation of c-Myc overexpressing gastric cancer cell lines. Thus, our findings highlight that gastric cancer can be induced by c-Myc overexpression through activation of the AKT/mTOR pathway.
2021-08-11 | GSE145583 | GEO
Project description:stomach microbiome shape in two gastric cancer subtypes
| PRJNA641258 | ENA
Project description:Metabolic reprogramming is a critical driver in the pathogenesis of gastric cancer (GC). However, the intricate regulatory mechanisms that govern this reprogramming and their role in GC progression remain inadequately understood. Here, we have elucidated that Methyltransferase-like 10 (METTL10) is a pivotal regulator of gastric tumorigenesis, significantly enhancing purine metabolism in GC cells. Mechanistically, METTL10 methylates and competes with the protein inhibitor of activated STAT3 (PIAS3) for binding to microphthalmia-associated transcription factor (MITF), thereby reducing the sumoylation and ubiquitination of MITF and subsequently activating purine metabolism. Moreover, the oncogenic effects of METTL10 in gastric tumorigenesis are contingent upon MITF and the methylation of lysine 442 in PIAS3, both of which are strongly correlated with poor clinical features. Additionally, we identified a compound, LZQ-02-023-01, which effectively mitigates the oncogenic activity of METTL10 in GC. These findings suggest that METTL10 is involved in purine metabolism reprogram to promote gastric cancer. These findings underscored METTL10's critical role in the metabolic reprogramming of purine metabolism and highlight its potential as a therapeutic target in the treatment of GC.
2026-01-05 | PXD057247 | Pride
Project description:Background: Patients undergoing weight-reducing Roux-en-Y gastric bypass (RYGB) have immediate positive effects on metabolic health, including type 2 diabetes (T2D). Refeeding via the secluded stomach, either by a gastrotube or after gastro-gastric fistulation result in T2D relapse and weight regain. The stomach therefore seems to play an active role in metabolism. Objectives: To explore histological and protein expression changes in the gastric mucosa before compared to after RYGB. Methods: Perioperatively, biopsies were taken in a non-paired manner from the stomach (fundus, corpus, antrum) in patients undergoing Sleeve Gastrectomy (SG) and patients >8 months postoperatively after RYGB by balloon-enteroscopy. The included SG and RYGB patients did not display any obvious mucosal or luminal pathology during surgery or the balloon-enteroscopies. The gastric biopsies both at perioperatively and postoperatively were prepared för histological evaluation and for quantitative (comparative) non-targeted proteomics. The results were compared by Volcano plots, Principal Component Analysis and STRING functional protein association networks. Results: Histologically the gastric mucosa looked normal in biopsies from all the different parts of the postoperative bypassed stomach with no clear differences compared to the perioperative samples. The perioperative biopsies generally contained significantly higher amounts of proteins involved in fatty acid metabolism, oxidative phosphorylation and ATP metabolic processes, citric acid cycle and the respiratory chain. Postoperative biopsies instead showed overall increased quantities of proteins associated with ribosomes, RNA-metabolic processes, the mitotic cycle and pancreatic secretion. Conclusions: The results provide novel insights into the mucosal proteome-changes in the secluded stomach following RYGB.
2025-07-17 | PXD065508 | Pride
Project description:Transcriptional profiling of circular RNA in stage III gastric cancer patient: Tumour vs. Normal mucosa tissue
2017-12-14 | GSE83521 | GEO
Project description:We analyzed DNA copy number alterations in 64 human gastric cancer samples and 8 gastric cancer cell lines using bacterial artificial chromosome (BAC) arrays based comparative genomic hybridisation (aCGH). Gastric cancer tumor tissue samples and cell lines vs normal blood samples
2012-11-05 | E-GEOD-33501 | biostudies-arrayexpress