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ACGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/- [Agilent-024427]

ABSTRACT: aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/- [Agilent-024427]

PROVIDER: PRJNA657193 | ENA |

REPOSITORIES: ENA

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aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/- [Agilent-027411]

Project description:aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/- [Agilent-027411]

| PRJNA657191 | ENA

aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/- [Agilent-024427]

Project description:Background and aims: P53 limits the self-renewal of stem cells from various tissue. A Loss of p53 in combination with other oncogenic events results in aberrant self-renewal and transformation of progenitor cells. Here, we investigated whether a loss of p53 as a single genetic lesion is sufficient to induce liver tumor formation. Methods: AlfpCre mice were crossed with Trp53 conditional knockout mice to achieve a liver-specific loss of Trp53. Results: The liver-specific loss of Trp53 results in liver tumor formation. A high percentage of the tumors showed a mixed differentiation of hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Conclusion: The liver-specific deletion of Trp53 is sufficient to induce liver tumor formation.

2021-01-22 | GSE156253 | GEO

aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/- [Agilent-027411]

2021-01-22 | GSE156252 | GEO

aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/-

Project description:aCGH analysis of liver tumors generated in C57BL/6J mice with a liver specific loss of Trp53-/-

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aCGH analysis of liver tumors generated in FAH-/- Trp53-/- mice, a mouse model of metabolic liver injury

Project description:aCGH analysis of liver tumors generated in FAH-/- Trp53-/- mice, a mouse model of metabolic liver injury

| PRJNA657190 | ENA

aCGH analysis of liver tumors generated in FAH-/- Trp53-/- and FAH-/- mice, a mouse model of metabolic liver injury

Project description:aCGH analysis of liver tumors generated in FAH-/- Trp53-/- and FAH-/- mice, a mouse model of metabolic liver injury

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