Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of Diaph1 knockout on gene expression of mouse livers on western diet for 16 weeks

ABSTRACT: Effect of Diaph1 knockout on gene expression of mouse livers on western diet for 16 weeks

PROVIDER: PRJNA657839 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12467618.fastq.gz	Fastqsanger.gz
	SRR12467619.fastq.gz	Fastqsanger.gz
	SRR12467620.fastq.gz	Fastqsanger.gz
	SRR12467621.fastq.gz	Fastqsanger.gz
	SRR12467622.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Effect of Diaph1 knockout on gene expression of mouse livers on western diet for 16 weeks

Project description:Diaph1 was knocked out in Ldlr-/- mice on western diet for 16 weeks and the effect of gene expression in liver was measured.

2023-03-14 | GSE156403 | GEO

The effects of myeloid-specific Lipa overexpression on the transcriptomic profile of aortic plaque macrophages in mice on the Ldlr-/- background and fed a Western diet for 16 weeks

Project description:We analyzed the transcriptomic profile of aortic macrophages directly sorted from atherosclerotic aortas of two groups of mice fed a Western diet for 16 weeks: (1) mice with LysMCre-mediated myeliod-specific Lipa overexpression on the Ldlr-/- background; (2) LysMCre-negative littermates on the Ldlr-/- background.

2025-08-01 | GSE285961 | GEO

Expression data from Control diet, Western diet and Western diet + DHA fed rats.

Project description:LV hypertrophy is associated with Western diet consumption, while intake of n-3 polyunsaturated fatty acids is associated with anti-hypertrophic effects. We treated rats for 12 weeks with either a Control diet, a Western diet or a Western + DHA diet. For each of the 3 dietary treatments there were 2 pooled samples of heart tissue (with each pooled sample representing 5 rats) for a total of 6 arrays. Microarray analysis identified 66 differentially expressed transcripts. Pathways were identified using Ingenuity and DAVID software. Array results from two pooled samples (5 rats in each pool) for n=10 per treatment group were used for comparisons. Comparisons between Western vs. Control, Western + DHA vs. Control and Western + DHA vs. Western diets was subjected to analysis to generate log fold changes. A dietary treatment of 12 weeks was used in an effort to produce LVH while limiting the development of comorbidities. Microarray analysis was performed on pooled samples, followed by qRT-PCR and Western blot analysis. Groups were Control, Western and Western + DHA. Comparisons between groups are expressed as LogFC (i.e. LogFC_WESvCTRL, LogFC_DHAVCTRL, LogFC_DHAvWES), available in Series supplementary files.

2013-11-22 | E-GEOD-52603 | biostudies-arrayexpress

Gene expression of livers from Lpcat3fl/fl and Lpcat3fl/fl Albumin-Cre mice on a western diet

Project description:The total abundance of phosphatidylcholine (PC) is known to influence lipoprotein production. However, the role of specific phospholipid species in lipid transport has been difficult to assess due to an inability to selectively manipulate membrane composition in vivo. Here we show that the LXR-regulated phospholipid remodeling enzyme lysophosphatidylcholine acyltransferase 3 (Lpcat3) is a critical determinant of membrane phospholipid composition and lipoprotein production. Mice lacking Lpcat3 in the liver show defects in lipoprotein production. The objective of generating this dataset was to analyze the effects of Lpcat3 loss of function on gene expression in mouse liver with a western diet challenge. This dataset compares gene expression in Lpcat3fl/fl and Lpcat3fl/fl Albumin-Cre liver samples from 16-week old male mice that were fed a western diet for 9 weeks since 7 weeks old. Each sample contains tissues from 5 mice.

2015-06-26 | E-GEOD-65353 | biostudies-arrayexpress

Expression data from Control diet, Western diet and Western diet + DHA fed rats.

2013-11-22 | GSE52603 | GEO

Mouse Liver: Tumors vs livers with transgene turned off for 4 weeks vs livers with transgene turned off for 12 weeks vs Normal

Project description:Transcriptional Profiling of mouse liver tissues comparing normal tissues, livers arising from transgene expression after hepatocy transplantation using the comparative hepatocyte growth assay, and livers with transgene turned off for 4 and 12 weeks. Experimental groups: Control normal liver; Endstage liver tumors, livers with transgene turned off for 4 weeks, and livers with transgene turned off for 12 weeks.

2014-07-15 | GSE59211 | GEO

Lungs from CYP1B1 knockout mice (or controls) fed a western diet for 10 weeks

Project description:Lungs from CYP1B1 knockout mice (or controls) fed a western diet for 10 weeks

| PRJNA935399 | ENA

Liver-specific deletion of Pten and atypical E2Fs in 16-weeks old mice.

Project description:RNA-sequencing analysis of liver gene expression after combinatorial liver-specific deletion of tumor suppressor genes in a mouse fatty liver disease and liver cancer model. Gene expression was determined at 16 weeks of age, before onset of liver tumor formation. Aim was to study how loss of atypical E2F transcription repressors affected gene expression in Pten-mutant livers.

2022-05-12 | GSE202546 | GEO

Gene expression profiling in thoracic aortas of 8 week and 16 week ApoE knockout mice on a western type diet

Project description:Identification of novel pathways in the development of atherosclerosis. Here, we are looking at changes in gene expression that occur in the aorta with the development of atherosclerosis Analysis used RNA from thoracic aortas from chow fed ApoE knockout mice as control samples for comparison to the experimental samples from 8 week and 16 week ApoE knockout mice fed a western-type diet

2015-02-03 | E-GEOD-65494 | biostudies-arrayexpress

Livers of mice fed an atherogenic diet for 6 or 24 weeks

Project description:To address the molecular basis for atherogenic diet-induced liver injury, we performed microarray analysis using livers at early (6 weeks) and pre-cirrhosis stages (24 weeks) in the development of steatohepatitis. The Atherogenic diet up-regulated the gene expression for fatty acid synthesis, inflammatory cytokines, oxidative stress, and fibrosis, and with down-regulation of fatty acid beta-oxidation. The addition of a high-fat component to the Atherogenic diet up-regulated the gene expression for fatty acid synthesis and transport pathways and down-regulated some of the antioxidant genes. Keywords: time-course

2006-09-19 | GSE5852 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data