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Olfactory stimulation regulates the birth of neurons that express specific odorant receptors

ABSTRACT: Olfactory stimulation regulates the birth of neurons that express specific odorant receptors

PROVIDER: PRJNA660168 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12544337_1.fastq.gz	Fastqsanger.gz
	SRR12544337_2.fastq.gz	Fastqsanger.gz
	SRR12544338_1.fastq.gz	Fastqsanger.gz
	SRR12544338_2.fastq.gz	Fastqsanger.gz
	SRR12544339_1.fastq.gz	Fastqsanger.gz

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Silencing of odorant receptor gene expression by G protein M-NM-2M-NM-3 signaling ensures the expression of one odorant receptor per olfactory sensory neuron

Project description:Olfactory sensory neurons express just one out of a possible ~1000 odorant receptor genes, reflecting an exquisite mode of gene regulation. In one model, once an odorant receptor is chosen for expression, other receptor genes are suppressed by a negative feedback mechanism, ensuring a stable functional identity of the sensory neuron for the lifetime of the cell. The signal transduction mechanism subserving odorant receptor gene silencing remains obscure, however. Here we demonstrate in the zebrafish that odorant receptor gene silencing is dependent on receptor activity. Moreover, we show that signaling through G protein M-NM-2M-NM-3 subunits is both necessary and sufficient to suppress the expression of odorant receptor genes, and likely acts through histone methylation to maintain the silenced odorant receptor genes in transcriptionally inactive heterochromatin. These results provide new insights linking receptor activity with the epigenetic mechanisms responsible for ensuring the expression of one odorant receptor per olfactory sensory neuron. Total 6 samples were analyzed-3 controls & 3 samples

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Project description:The objectives of this study were to use unilateral naris occlusion (UNO) in order to characterize the effects of olfactory deprivation on the relative abundance of newly generated olfactory sensory neurons that express specific odorant receptors.

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Olfactory stimulation regulates the birth of neurons that express specific odorant receptors

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-10-07 | GSE157120 | GEO