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Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients

ABSTRACT: Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients

PROVIDER: PRJNA660599 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12560572.fastq.gz	Fastqsanger.gz
	SRR12560573.fastq.gz	Fastqsanger.gz
	SRR12560574.fastq.gz	Fastqsanger.gz
	SRR12560575.fastq.gz	Fastqsanger.gz
	SRR12560576.fastq.gz	Fastqsanger.gz

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Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients.

Project description:The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cells from melanoma metastases showed enriched expression of inflammatory response genes. Publicly available single B cell data from the tumor microenvironment revealed a negative correlation between TNFα expression and response to immune checkpoint blockade. These findings suggest that B cells contribute to tumor growth via the production of inflammatory cytokines. Possibly, these B cells are different from tertiary lymphoid structure-associated B cells, which have been described to correlate with favorable clinical outcome of cancer patients. Further studies are required to identify and characterize B cell subsets and their functions promoting or counteracting tumor growth, with the aim to identify biomarkers and novel treatment targets.

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