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RNA-seq of Runx3 cKO SFZ/DZ chondrocytes.

ABSTRACT: RNA-seq of Runx3 cKO SFZ/DZ chondrocytes.

PROVIDER: PRJNA661298 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12582674.fastq.gz	Fastqsanger.gz
	SRR12582675.fastq.gz	Fastqsanger.gz
	SRR12582676.fastq.gz	Fastqsanger.gz
	SRR12582677.fastq.gz	Fastqsanger.gz
	SRR12582678.fastq.gz	Fastqsanger.gz

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RNA-seq of Runx3 cKO SFZ/DZ chondrocytes.

Project description:Purpose: To demonstrate Runx3's association with organizing the extracellular matrix in SFZ/DZ chondrocytes. Method: RNA samples were collected from SFZ/DZ chondrocytes of 5-day-old Col2a1-Cre;Runx3fl/fl and Runx3fl/fl mice. Results: 18 genes were up- or down-regulated by more than 2-fold in the Runx3 knockout in SFZ. Conclusions: However, genes organizing the extracellular matrix were down-regulated in Runx3 cKO DZ chondrocytes.

2020-09-04 | GSE157433 | GEO

ChIP-seq of Runx3 in SFZ chondrocytes.

Project description:Purpose: To demonstrate Runx3's association with organizing the extracellular matrix in SFZ chondrocytes. Method: Fragment DNA samples were collected by using Anti-FLAG or IgG, from SFZ chondrocytes treated with lipofection of RUNX3-FLAG Results: 21,730 raw peaks met the peak calling criterion. Conclusions: By GO analysis, the extracellular structure organization and collagen fibril organization terms were the most significantly enriched.

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ChIP-seq of Runx3 in SFZ chondrocytes.

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Expression data from SFZ cells and costal chondrocytes

Project description:To understand difference between SFZ cells and costal chondrocytes, total RNAs from SFZ cells and costal chondrocytes were analyzed by microarray.

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Expression data from SFZ cells and costal chondrocytes

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RNA-seq of Runx2 cKO primary chondrocytes.

Project description:Purpose: To demonstrate Runx2's association with organizing the extracellular matrix in primary chondrocytes. Method: RNA samples were collected from primary chondrocytes of 5-day-old Col2a1-CreERT2;Runx2fl/fl and Runx2fl/fl mice, cultured with or without IL-1beta. Results: Thirty-three genes cultured without IL-1beta and 45 genes with IL-1beta were up- or down-regulated by more than 2-fold in the Runx2 knockout in primary chondrocytes. Conclusions: Genes including collagen fibers were down-regulated in Runx2 cKO primary chondrocytes.

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RNA-seq of Runx2 cKO primary chondrocytes.

Project description:RNA-seq of Runx2 cKO primary chondrocytes.

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Project description:Ezh2-cKO or Utx-cKO in chondrocytes initiate metachondromatosis which containing both exostoses and enchondromas. To figure out whether the exostoses of Ezh2-cKO and Utx-cKO were the similar tumore, we compared the transcriptional profiles using RNA-sequencing of exostoses from Ezh2-cKO and Utx-cKO mice.

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2019-11-12 | PXD007511 | Pride

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