Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dual DNA/protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia (CUT&RUN)

ABSTRACT: Dual DNA/protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia (CUT&RUN)

PROVIDER: PRJNA664954 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12692205_1.fastq.gz	Fastqsanger.gz
	SRR12692205_2.fastq.gz	Fastqsanger.gz
	SRR12692206_1.fastq.gz	Fastqsanger.gz
	SRR12692206_2.fastq.gz	Fastqsanger.gz
	SRR12692207_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Dual DNA/protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia

Project description:Dual DNA/protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia

| PRJNA664946 | ENA

Dual DNA/protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia (ATAC-Seq)

Project description:Dual DNA/protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia (ATAC-Seq)

| PRJNA664953 | ENA

Dual DNA/protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia

Project description:The architecture of chromatin specifies eukaryotic cell identity by controlling transcription factor access to sites of gene regulation. Here we describe a dual transposase/peroxidase approach, integrative DNA And Protein Tagging (iDAPT), which detects both DNA (iDAPT-seq) and protein (iDAPT-MS) associated with accessible regions of chromatin. In addition to direct identification of bound transcription factors, iDAPT enables the inference of their gene regulatory networks, protein interactors, and regulation of chromatin accessibility. We applied iDAPT to profile the epigenomic consequences of granulocytic differentiation of acute promyelocytic leukemia, yielding previously undescribed mechanistic insights with potential therapeutic implications. Our findings demonstrate the power of iDAPT as a discovery platform for both the dynamic epigenomic landscapes and their transcription factor components associated with biological phenomena and disease.

2020-11-02 | PXD022252 | Pride

Dual DNA/protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia (CUT&RUN)

2020-11-01 | GSE158348 | GEO

Dual DNA/protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia (ATAC-Seq)

2020-11-01 | GSE158346 | GEO

Dual DNA and protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia.

Project description:The architecture of chromatin regulates eukaryotic cell states by controlling transcription factor access to sites of gene regulation. Here we describe a dual transposase-peroxidase approach, integrative DNA and protein tagging (iDAPT), which detects both DNA (iDAPT-seq) and protein (iDAPT-MS) associated with accessible regions of chromatin. In addition to direct identification of bound transcription factors, iDAPT enables the inference of their gene regulatory networks, protein interactors and regulation of chromatin accessibility. We applied iDAPT to profile the epigenomic consequences of granulocytic differentiation of acute promyelocytic leukemia, yielding previously undescribed mechanistic insights. Our findings demonstrate the power of iDAPT as a platform for studying the dynamic epigenomic landscapes and their transcription factor components associated with biological phenomena and disease.

| S-EPMC8272231 | biostudies-literature

Dual DNA/protein tagging of open chromatin unveils dynamics of epigenomic landscapes in leukemia

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-10-31 | GSE158350 | GEO

Open chromatin landscapes of breast cancer cell lines

Project description:Open chromatin landscapes of breast cancer cell lines

| PRJNA928428 | ENA

Open chromatin landscapes of breast cancer cell lines

Project description:Chromatin openness is a good indicator of non-coding regulatory elements. Here, we generated ATAC-seq of 8 breast cancer cell lines covering different breast cancer subtypes as an overview of the open chromatin landscapes.

2024-11-13 | GSE223812 | GEO