Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Romboutsia sp.

ABSTRACT: Romboutsia sp. Raw sequence reads

PROVIDER: PRJNA665801 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12717855.fastq.gz	Fastqsanger.gz
	SRR12717856.fastq.gz	Fastqsanger.gz
	SRR12717857.fastq.gz	Fastqsanger.gz
	SRR12717858.fastq.gz	Fastqsanger.gz
	SRR12717859.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 40

Similar Datasets

Romboutsia

Project description:Romboutsia sp. overview

| PRJNA904003 | ENA

Romboutsia sp.

Project description:Description of new Romboutsia species

| PRJNA393817 | ENA

Romboutsia lituseburensis

Project description:Romboutsia lituseburensis overview

| PRJNA484818 | ENA

Genome sequence of Romboutsia lituseburensis

Project description:Genome sequence of Romboutsia lituseburensis

| PRJEB7306 | ENA

Genome sequence of Romboutsia str. Frifi

Project description:Genome sequence of Romboutsia str. Frifi

| PRJEB7106 | ENA

Morus alba Raw protein sequence reads

Project description:Morus alba L. Raw protein sequence reads and sequence

2024-02-08 | PXD049451 |

The Romboutsia ilealis and derived 2-oxindole-3-aceic acid regulate obesity-associated lipid accumulation via PSMD3-mediated YTHDF2 deubiquitination

Project description:Specific gut microbiota is critically involved in metabolic diseases, including obesity. Through analysis of gut microbiota in diabetic patients and animal models, it was found that Romboutsia ilealis is closely associated with obesity. Here, our findings show that oral administration of Romboutsia ilealis significantly alleviates diet-induced obesity and metabolic dysfunction. Interestingly, this effect occurs not through modulation of food intake or energy expenditure, but by regulating lipid absorption and metabolism in the gut. Additionally, metabolomics analysis identified 2-oxindole-3-acetic acid (OAA) as the key metabolite involved in the regulation of obesity by Romboutsia ilealis. Its regulatory effect on intestinal lipid absorption was further validated both in vitro and in vivo. Mechanistically, using biotin-labeled OAA combined with proteomic analysis, we found that OAA directly interacts with the deubiquitin enzyme PSMD3, increasing the ubiquitination level of m6A binding protein YTHDF2 and reducing its protein stability, thereby enhancing intestinal lipid absorption. Furtherly, through m6A-seq, we discovered that YTHDF2 negatively regulates the expression of RXRB by recognizing the m6A sites on its mRNA, which in turn downregulates the expression of lipid absorption and transport proteins CD36 and FABP2, ultimately inhibiting intestinal lipid absorption. In summary, our findings reveal that Romboutsia ilealis and OAA regulate obesity-associated lipid accumulation through PSMD3-mediated deubiquitination of YTHDF2, suggesting that they represent novel prebiotics and probiotics with potential as therapeutic agents against obesity.

2024-12-19 | GSE284540 | GEO

Project description:WTCCC2 project Schizophrenia (SP) samples

| EGAD00010000262 | EGA

Romboutsia lituseburensis strain:MY01

Project description:Romboutsia lituseburensis strain:MY01 Genome sequencing and assembly

| PRJNA869839 | ENA

RNA-seq based transcriptome of Nesterenkonia sp. AN1

Project description:The transcript profiles of Nesterenkonia sp. AN1 grown at 5 ºC (Cold) and 21 ºC (Topt) were acccessed to evaluate the cold reposnse of this Antarctic Nesterenkonia strain. The strain was grown in triplicates at the optimum growth temperature of 21 ºC and a test temperature of 5 ºC. Total RNA was extracted from two replicate samples for each treatment condition and the total RNA was enriched for mRNA. RNA-seq was done using Illumina Miseq platform at Inqaba Biotech, South Africa. The reads were mapped against the genome sequence of Nesterenkonia sp. AN1 (obtained from NCBI database) and assesed for differeential gene expression using CLC Genomics Workbench 7.5.

2015-07-22 | GSE71132 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data