Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential transcriptome of human dendritic cells at first contact with Trypanosoma cruzi reveals response to virus as a central unexplored pathway

ABSTRACT: Differential transcriptome of human dendritic cells at first contact with Trypanosoma cruzi reveals response to virus as a central unexplored pathway

PROVIDER: PRJNA667258 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12769450_1.fastq.gz	Fastqsanger.gz
	SRR12769450_2.fastq.gz	Fastqsanger.gz
	SRR12769451_1.fastq.gz	Fastqsanger.gz
	SRR12769451_2.fastq.gz	Fastqsanger.gz
	SRR12769452_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Differential transcriptome of human dendritic cells at first contact with Trypanosoma cruzi reveals response to virus as a central unexplored pathway

Project description:Chagas disease is a notorious public health problem worldwide. However, the pathology is still poorly understood in humans and dendritic cells (DCs) have a determinant role during infection that could help to understand what happens with immune response during the first contact. Here we performed a transcriptomic analysis of the interaction between DCs from three human donors and the infective forms of T. cruzi for 12 h. 468 differentially expressed genes (DEGs) were found in DCs after infection. KEGG and GO enrichment analysis showed that most of DEGs are involved in pathways related to virus infection and intracellular receptors, as NOD and RIG-I -like receptors. Some of these DEGs were validated through RT-qPCR, corroborating the transcriptome data. Cytokine measurement partially corresponded to the transcript levels. In conclusion, this study has revealed the virus response as an unexplored pathway in Chagas disease, which brings new perspectives for this pathology.

2021-03-31 | GSE158986 | GEO

aCGH Trypanosoma cruzi G vs D11.

Project description:Comparative genomic analysis of Trypanosoma cruzi G with Trypanosoma cruzi D11.

2022-03-06 | GSE197870 | GEO

Trypanosoma cruzi CLB vs Trypanosoma rangeli and Trypanosoma conorhini

Project description:Comparative genomic analysis of T. cruzi CLB vs Trypanosoma rangeli (strains SC, Choachí, C23, H14, R1625 and PIT10) and Trypanosoma conorhini

2023-04-11 | GSE229354 | GEO

Trypanosoma cruzi conserved proteome microarray

Project description:Antibody recognition of Trypanosoma cruzi conserved proteins was assessed by evaluating pools of patient IgG samples on microarrays of 400,000 peptides covering these proteins as 15-mers with an overlap of 13 amino acids.

2024-02-28 | GSE235074 | GEO

Trypanosoma cruzi Dm28c

Project description:Trypanosoma cruzi

| PRJNA260279 | ENA

Trypanosoma cruzi

Project description:Trypanosoma cruzi mitochondrial DNA

| PRJNA713613 | ENA

DualSeq Trypanosoma cruzi

Project description:DualSeq Trypanosoma cruzi

| PRJEB84364 | ENA

Trypanosoma cruzi

Project description:Trypanosoma cruzi Raw sequence reads

| PRJNA315252 | ENA

Trypanosoma cruzi Dm28c

Project description:Trypanosoma cruzi FAIRE-seq

| PRJNA763084 | ENA

Transcriptome profile of Trypanosoma cruzi-infected cells

Project description:As Trypanosoma cruzi, the etiological agent of Chagas disease, multiplies in the cytoplasm of nucleated host cells, infection with this parasite is highly likely to affect host cells. We performed an exhaustive transcriptome analysis of T. cruzi-infected HeLa cells using an oligonucleotide microarray containing probes for greater than 47,000 human gene transcripts. In comparison with uninfected cells, those infected with T. cruzi showed greater than threefold up-regulation of 41 genes and greater than threefold down-regulation of 23 genes. Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) of selected, differentially expressed genes confirmed the microarray data. Many of these up- and down-regulated genes were related to cellular proliferation, including seven up-regulated genes encoding proliferation inhibitors and three down-regulated genes encoding proliferation promoters, strongly suggesting that T. cruzi infection inhibits host cell proliferation, which may allow more time for T. cruzi to replicate and produce its intracellular nests. These findings provide new insight into the molecular mechanisms by which intracellular T. cruzi infection influences the host cell, leading to pathogenicity. Keywords: infection response

2008-02-06 | GSE7047 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data