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MiRNA expression profiles of multiple myeloma

ABSTRACT: miRNA expression profiles of multiple myeloma

PROVIDER: PRJNA668113 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12795565.fastq.gz	Fastqsanger.gz
	SRR12795566.fastq.gz	Fastqsanger.gz
	SRR12795567.fastq.gz	Fastqsanger.gz
	SRR12795568.fastq.gz	Fastqsanger.gz
	SRR12795569.fastq.gz	Fastqsanger.gz

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miRNA expression profiles of multiple myeloma

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Project description:miRNA profiling in multiple myeloma - microRNAs represent a class of noncoding regulators of gene expression implicated in several biological and pathophysiological processes, including cancer. We investigate here their role in multiple myeloma using miChip-arrays interrogating 559 miRNAs in 92 purified myeloma-, MGUS-, normal plasma cell- and myeloma cell line samples. Impact on gene expression is assessed by Affymetrix U133 2.0 DNA-microarrays in 741 samples including two cohorts of 332 and 345 myeloma patients; chromosomal aberrations are assessed by iFISH, survival for 247 and 345 patients undergoing up-front high-dose therapy and autologous stem cell transplantation. Compared to normal plasma cells, 67/559 (12%) miRNAs are differentially expressed with fold changes of 4.6 to -3.1 in myeloma-, 20 (3.6%) in MGUS-samples, and three (0.5%) between MGUS- and myeloma-samples. Expression of miRNAs is associated with biological and pathophysiological parameters, i.e. proliferation, chromosomal aberrations, e.g. t(4;14), tumor mass, and gene expression-based high-risk scores. This holds true for target-gene signatures of regulated mRNAs. miRNA-expression confers prognostic significance for event-free (72/559) and overall survival (69/559), as do respective target-gene signatures. In conclusion, the miRNome of myeloma confers a pattern of small changes of individual miRNAs compared to normal plasma cells impacting on gene expression, biological functions, and survival.

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Project description:tRNA related fragments(tRF) and tRNA halves(tiRNA) are novel class of short non-coding RNA derived from tRNAs. Using RNA sequencing, we evaluated the tRFs/tiRNAs expression profiles in relapsed/refractory multiple myeloma and multiple myeloma patients. Bioinformatics analyses indicated that tRFs/tiRNAs may be involved in the progression and drug-resistance of multiple myeloma.

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Project description:Samples in this series are pre-treatment bone marrow aspirates from multiple myeloma patients. Keywords = Multiple Myeloma, Bone Marrow, Pre-Treatment Keywords: other

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Identification of aberrant miRNA expression in multiple myeloma

Project description:To identify aberrant miRNAs involved in the pathogenesis of multiple myeloma, we performed miRNA expression profiling of a total of 27 samples consisting of 19 clinical specimens, 8 myeloma cell lines and 3 normal peripheral blood samples. The microarray data were analysed by GeneSpring Software v13.0. We had identified 1799 miRNAs, which were differentially expressed by >2.0 fold change at p<0.05. Out of 1799 miRNAs, 1791 and 8 of them were up-regulated and down-regulated, respectively in myeloma group compared to the normal control group. Expression of 2 miRNAs (miR-150-5p and miR-4430) were verified by real-time PCR using the same RNA samples (20-22 samples were used) using SYBR Green. The real-time PCR confirmed that the expression of the miRNAs were consistent with microarray data.

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