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Transcriptomic deconvolution of human endometrial cell types

ABSTRACT: Transcriptomic deconvolution of human endometrial cell types

PROVIDER: PRJNA668163 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12797318_1.fastq.gz	Fastqsanger.gz
	SRR12797318_2.fastq.gz	Fastqsanger.gz
	SRR12797319_1.fastq.gz	Fastqsanger.gz
	SRR12797319_2.fastq.gz	Fastqsanger.gz
	SRR12797320_1.fastq.gz	Fastqsanger.gz

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Transcriptomic deconvolution of human endometrial cell types

Project description:The human endometrium is a highly heterogeneous tissue comprising multiple cell-types and cellular states that change in cycle-dependent manner. This tissue heterogeneity is a major drawback when interpreting bulk (whole biopsy) transcriptomic data. To address this hurdle, RNA-seq analysis was performed on four isolated stromal cell populations [SUSD2+ perivascular stromal cells (PVCs), endometrial stromal cells (EnSCs), SUSD2+ clonal cells (MSCs), and clonal transit amplifying cells (TAs)], glandular epithelial cells, uNK cells, and matched whole tissue. Transcriptomic data were obtained for 3 whole endometrial biopsies and 6 matched, purified cell populations.

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