Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

HubMAP: A Spatially Resolved Molecular Atlas of Human Endothelium

ABSTRACT: HubMAP: A Spatially Resolved Molecular Atlas of Human Endothelium

PROVIDER: PRJNA671244 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

HubMAP: A Spatially Resolved Molecular Atlas of Human Endothelium

Project description:HubMAP: A Spatially Resolved Molecular Atlas of Human Endothelium

| PRJNA671245 | ENA

A spatially resolved single cell atlas of human gastrulation

Project description:A spatially resolved single cell atlas of human gastrulation

| PRJEB40781 | ENA

A single-cell and spatially resolved atlas of human breast cancers

Project description:This study presents a single cell and spatially resolved transcriptomics analysis of human breast cancers. We develop a single cell method of intrinsic subtype classification (scSubtype) to reveal recurrent neoplastic cell heterogeneity. Immunophenotyping using CITE-Seq provides high-resolution immune profiles, including novel PD-L1/PD-L2+ macrophage populations associated with clinical outcome. Mesenchymal cells displayed diverse functions and cell surface protein expression through differentiation within 3 major lineages. Stromal-immune niches were spatially organized in tumors, offering insights into anti-tumor immune regulation. Using single cell signatures, we deconvoluted large breast cancer cohorts to stratify them into nine clusters, termed ‘ecotypes’, with unique cellular compositions and clinical outcomes. This study provides a comprehensive transcriptional atlas of the cellular architecture of breast cancer.

2021-06-24 | GSE176078 | GEO

A single-cell and spatially resolved atlas of human breast cancers

Project description:A single-cell and spatially resolved atlas of human breast cancers

| PRJNA734812 | ENA

Spatially and cell-type resolved quantitative proteomic atlas of healthy human skin

Project description:Human skin provides both physical integrity and immunological protection from the external environment, using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins of skin have not been systematically characterized. Here, we combined advanced tissue dissection methods, flow cytometry and state-of-the-art proteomics to describe a spatially-resolved quantitative proteomic atlas of human skin. We quantified 10,701 proteins as a function of their spatial location and cellular origin. The resulting protein atlas and our initial data analyses demonstrate the value of proteomics for understanding cell-type diversity within the skin. We describe here the quantitative distribution of structural proteins, known and novel proteins specific to cellular subsets and those with specialized immunological funtions such as cytokines and chemokines. We anticipate this proteomic atlas of human skin will become an essential community resource for basic and translational research (www.skin.science).

2020-11-18 | PXD019909 | Pride

A spatially resolved single cell genomic atlas of the adult human breast

Project description:A spatially resolved single cell genomic atlas of the adult human breast

| PRJNA801681 | ENA

A spatially resolved multiomic single-cell atlas of soybean development

Project description:Cis-regulatory elements (CREs) precisely control the spatiotemporal gene expression in cells. Using a spatially resolved single-cell atlas of gene expression and chromatin accessibility across ten soybean tissues, we identified 103 distinct cell types and 303,199 accessible chromatin regions (ACRs). Nearly 40% of ACRs showed cell-type-specific patterns and were enriched for transcription factor (TF) binding motifs controlling cell-type specification and maintenance. We identified non-cell autonomous activity of NIN-LIKE PROTEIN 7 (NLP7), the Nodule Inception (NIN) gene regulatory network and de novo enriched TF motifs in the nodule infected cells. With comprehensive developmental trajectories for endosperm and embryo, we found that 13 sucrose transporters, sharing the DOF11 binding motif, were co-up-regulated in late peripheral endosperm and identified the key embryo cell-type specification regulators during embryogenesis, including a homeobox TF that promotes cotyledon parenchyma identity. This resource provides a valuable foundation for analyzing gene regulatory programs in soybean cell types across tissues and life stages.

2024-07-05 | GSE270392 | GEO

A spatially resolved single cell genomic atlas of the adult human breast [visium]

Project description:A spatially resolved single cell genomic atlas of the adult human breast [visium]

| PRJNA983280 | ENA

A spatially resolved single cell genomic atlas of the adult human breast [scRNA_cells]

Project description:A spatially resolved single cell genomic atlas of the adult human breast [scRNA_cells]

| PRJNA985695 | ENA

A spatially resolved single cell genomic atlas of the adult human breast [snRNA_nuclei]

Project description:A spatially resolved single cell genomic atlas of the adult human breast [snRNA_nuclei]

| PRJNA983286 | ENA