Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells (ChIP-seq H3K27me3 H3K4me3)

ABSTRACT: Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells (ChIP-seq H3K27me3 H3K4me3)

PROVIDER: PRJNA682224 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13187546.fastq.gz	Fastqsanger.gz
	SRR13187547.fastq.gz	Fastqsanger.gz
	SRR13187548.fastq.gz	Fastqsanger.gz
	SRR13187549.fastq.gz	Fastqsanger.gz
	SRR13187550.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 16

Similar Datasets

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells (ChIP-seq H3K27me3 H3K4me3)

Project description:Hematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here, we performed an integrated analysis of transcriptome and chromatin accessibility of aged HSCs and downstream progenitors. Alterations in chromatin accessibility preferentially took place in HSCs with aging, which gradually resolved with differentiation. Differentially open accessible regions (open DARs) in aged HSCs showed enrichment of binding motifs of the STAT, ATF, and CNC family transcription factors that are activated in response to external stresses, and most of them comprised active, primed , and inactive enhancers. Genes linked to open DARs showed significantly higher levels of basal expression and their expression reached significantly higher peaks after cytokine stimulation in aged HSCs than in young HSCs, suggesting that open DARs contribute to augmented transcriptional responses under stress conditions. These results indicate that the ongoing and/or history of exposure to external stresses is epigenetically inscribed in HSCs to augment their responses to external stimuli.

2020-12-05 | GSE162570 | GEO

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

Project description:Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

| PRJNA682581 | ENA

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells (EZH2_KO_HSC)

Project description:Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells (EZH2_KO_HSC)

| PRJNA682587 | ENA

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells

Project description:This SuperSeries is composed of the SubSeries listed below. Hematopoietic stem cells (HSCs) exhibit considerable cell-intrinsic changes with age. Here, we performed an integrated analysis of transcriptome and chromatin accessibility of aged HSCs and downstream progenitors. Alterations in chromatin accessibility preferentially took place in HSCs with aging, which gradually resolved with differentiation. Differentially open accessible regions (open DARs) in aged HSCs showed enrichment of binding motifs of the STAT, ATF, and CNC family transcription factors that are activated in response to external stresses, and most of them comprised active, primed , and inactive enhancers. Genes linked to open DARs showed significantly higher levels of basal expression and their expression reached significantly higher peaks after cytokine stimulation in aged HSCs than in young HSCs, suggesting that open DARs contribute to augmented transcriptional responses under stress conditions. These results indicate that the ongoing and/or history of exposure to external stresses is epigenetically inscribed in HSCs to augment their responses to external stimuli.

2020-12-05 | GSE162662 | GEO

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells(ATAC-seq)

Project description:Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells(ATAC-seq)

| PRJNA682201 | ENA

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells (RNA-seq)

Project description:Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells (RNA-seq)

| PRJNA682381 | ENA

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells(ATAC-seq)

2020-12-05 | GSE162551 | GEO

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells (RNA-seq)

2020-12-05 | GSE162607 | GEO

Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells (single cell ATAC-seq)