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Single-cell RNA sequencing analysis of mouse cardiac tissues with myocardial infarction

ABSTRACT: Single-cell RNA sequencing analysis of mouse cardiac tissues with myocardial infarction

PROVIDER: PRJNA688313 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13316475.fastq.gz	Fastqsanger.gz
	SRR13316476.fastq.gz	Fastqsanger.gz
	SRR13316477.fastq.gz	Fastqsanger.gz
	SRR13316478.fastq.gz	Fastqsanger.gz
	SRR17525678.fastq.gz	Fastqsanger.gz

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Single-cell RNA sequencing analysis of mouse cardiac tissues with myocardial infarction

Project description:To investigate the transcriotome alteration in myocardial infarction (MI)-associated cells, we performed RNA sequcening analysis with single cells derived from mouse infarcted cardiac tissues or normal left ventricle (LV). Particularly, cardiac endothelial cells (ECs) were traced using a Cdh5-Cre;LSL-tdTomatom system.

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Project description:The outcome of cardiac repair post myocardial infarction is highly dependent on the balance between inflammation and fibrosis, which can lead to adverse ventricular remodeling and failure or early cardiac rupture. In order to profile the dynamic response of the interstitium to cardiac ischemic injury, we performed unbiased single cell RNA Sequencing (scRNAseq) on cardiac interstitial cells at homeostasis and 1, 3, 5, 7, 14, 28 days post-injury using transgenic mice on C57bl/6j background (B6), expressing ZsGreen under the control of the epicardial marker Wt1 (Wt1Cre;RosaZsgreenf/+). About 38,600 cells were captured using the 10xChromium technology. To gain insights on how cell composition and transcriptome can affect the predisposition to cardiac rupture, we compared the data on B6 background with 129S1/SvlmJ (129) mice sham and d3 post-MI (time point proceeding the rupture), capturing about 13,000 additional cells.

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