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A mechanism of cooling hot tumors: lactate attenuates inflammation in dendritic cells

ABSTRACT: A mechanism of cooling hot tumors: lactate attenuates inflammation in dendritic cells

PROVIDER: PRJNA688644 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13327834.fastq.gz	Fastqsanger.gz
	SRR13327835.fastq.gz	Fastqsanger.gz
	SRR13327836.fastq.gz	Fastqsanger.gz
	SRR13327837.fastq.gz	Fastqsanger.gz
	SRR13327838.fastq.gz	Fastqsanger.gz

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A mechanism of cooling hot tumors: lactate attenuates inflammation in dendritic cells

Project description:A mechanism of cooling hot tumors: lactate attenuates inflammation in dendritic cells

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A mechanism of cooling hot tumors: lactate attenuates inflammation in dendritic cells

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A mechanism of cooling hot tumors: lactate attenuates inflammation in dendritic cells [BMDCs]

Project description:Lactic acid (LA) accumulation in the tumour environment occurs as a result of the accelerated glucose metabolism in tumour cells, the so-called Warburg effect. Because TLR4 agonists are one of the damage-associated molecular patterns, which are important stimulators of dendritic cells in the tumour microenvironment, we assessed the effects of LA on the response to LPS, the TLR4 ligand.

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A mechanism of cooling hot tumors: Lactate attenuates inflammation in dendritic cells.

Project description:Turning non-inflamed (cold) tumors into inflamed (hot) tumors is important for maximizing the effect of immune checkpoint inhibitors (ICIs) against malignancies. We showed that lactate, a product of the Warburg effect, inhibited the efficacy of ICIs and suppressed IL-12 p40 expression in dendritic cells (DCs) through reducing NF-κB p65, p50, and c-Rel DNA-binding activity to the IL-12 p40 promoter. Additionally, lactate promoted the expression of early growth response protein 1 (EGR1), whose expression was increased in human invasive melanoma compared with non-invasive melanoma. We also found that EGR1 interacts with serum response factor (SRF) and represses the expression of CD80 in DCs. These findings suggest that lactate and its induced EGR1 are key factors that turn hot tumors into cold tumors and may represent targets in cancer treatment with ICIs.

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A mechanism of cooling hot tumors: lactate attenuates inflammation in dendritic cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-08-23 | GSE163978 | GEO

Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis

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Evaporative cooling signals for wound healing in plants

Project description:Repairing a damaged body part is critical for the survival of an organism. Tissue damage induces rapid responses to activate downstream events including defense, regeneration and wound healing. Despite accumulating knowledge of early wound signaling including the orchestrated actions of phytohormones, electric circus and reactive oxygen species, our knowledge about the end point of a wound response - wound healing, is still limited. We observed that a local temperature reduction associated with the activation of cold-responsive genes occurred at wounding site on Arabidopsis leaves, which was likely caused by evaporative cooling. The disappearance of localized cooling and restoration of cold responsive genes to a steady state could be used as a quantitative readout of wound healing. Based on these observations, we developed a deep learning pipeline to monitor the dynamics of wound healing. We found that CBFs transcription factors relay injury-induced cooling signal to wound healing. Thus, our work provides a tool to quantify wound healing in plants and advances our understanding of tissue repair in plants.

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