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Innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin

ABSTRACT: Innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin

PROVIDER: PRJNA691599 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13422544.fastq.gz	Fastqsanger.gz
	SRR13422545.fastq.gz	Fastqsanger.gz
	SRR13422546.fastq.gz	Fastqsanger.gz
	SRR13422547.fastq.gz	Fastqsanger.gz
	SRR13422548.fastq.gz	Fastqsanger.gz

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Innate immune responses by bronchial epithelial cells exposed to the bacterial component flagellin

Project description:RNAseq was used to measure the transciptional respose of human bronchial epithelium (HBE) to the bacterial component flagellin with particular emphasis on innate immunity and metabolism.

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Bronchial epithelial cells transcriptomics upon flagellin stimulation (Microarray)

Project description:Innate immune memory is a new concept describing ability of innate myeloid and lymphoid cells to gain memory characteristics after transient stimulation, resulting in an nonspecific modified response upon secondary challenge. In recent work, we demonstrated that bronchial epithelial cells, non immune cells, that are the first immune cells of the lower respiratory tract to encounter pathogens were capable of innate immune memory after pre-exposure to Pseudomonas aeruginosa flagellin. In the present study we identified chromatin modifications induced by flagellin pre-exposure that sustain reprogramming of transcriptional patterns. We researched chromatin structure modifications responsible for the modulation of gene expression and thus of innate memory induced by the exposure of cells to flagellin.

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Bronchial epithelial cells accessibility upon flagellin stimulation (ATAC-Seq)

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Epigenetic reprogramming involved in bronchial epithelial cells memory induced by flagellin stimulation

Project description:Innate immune memory is a new concept describing ability of innate myeloid and lymphoid cells to gain memory characteristics after transient stimulation, resulting in an nonspecific modified response upon secondary challenge. In recent work, we demonstrated that bronchial epithelial cells that are non immune cells, the first immune cells of the lower respiratory tract to encounter pathogens were capable of innate immune memory after pre-exposure to Pseudomonas aeruginosa flagellin. In the present study we identified chromatin modifications induced by flagellin pre-exposure that sustain reprogramming of transcriptional patterns. We researched chromatin structure modifications responsible for the modulation of gene expression and thus of innate memory induced by the exposure of cells to flagellin.

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Bronchial epithelial cells transcriptomics upon flagellin stimulation (Microarray)

Project description:Bronchial epithelial cells transcriptomics upon flagellin stimulation (Microarray)

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Project description:Bronchial epithelial cells accessibility upon flagellin stimulation (ATAC-Seq)

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Single-cell transcriptomics reveals subset-specific metabolic profiles underpinning the bronchial epithelial response to flagellin

Project description:Airway epithelial cells represent the first line of defense against respiratory pathogens. Flagellin drives the motility of many mucosal pathogens and has been suggested as an immune enhancing adjunctive therapeutic in infections of the airways. This study leveraged single-cell RNA sequencing to determine cell-specific effects of flagellin in primary human bronchial epithelial cells growing in air-liquid interface. Seven cell clusters were identified, including ciliated cells, ionocytes and several states of basal and secretory cells, of which only inflammatory basal cells and inflammatory secretory cells demonstrated a proportional increase in response to flagellin. Inflammatory secretory cells showed evidence of metabolic reprogramming toward aerobic glycolysis, whilst in inflammatory basal cells transcriptome profiles indicated enhanced oxidative phosphorylation. Inhibition of mTOR prevented the shift to glycolysis and reduced inflammatory gene transcription specifically in inflammatory secretory cells. This data demonstrates the functional heterogeneity of the human airway epithelium upon exposure to flagellin.

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Transcriptomic profile of murine macrophage RAW264.7 in response to Salmonella flagellin

Project description:Macrophages are an important component of the innate immune system. Flagellin has been extensively studied for its adjuvant activity owing to its TLR5 and NLRC4 binding sites. However, few studies have comprehensively investigated the effects of flagellin in macrophages using transcriptome sequencing. In this study, RNA sequencing (RNA-seq) was used to analyze the expression patterns of RAW264.7 cells induced by flagellin (FliC) of Salmonella typhimurium compared with unstimulated cells, to identify novel transcriptomic signatures in macrophages.

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flagellin

Project description:Flagellin diversity

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Epigenetic reprogramming involved in bronchial epithelial cells memory induced by flagellin stimulation

Project description:Epigenetic reprogramming involved in bronchial epithelial cells memory induced by flagellin stimulation

| PRJNA944248 | ENA